Western Blot (WB)
(Western Blot analysis of Bcl-6 on NIH-3T3 cell lysate using anti-Bcl-6 antibody at 1/500 dilution.)
Rabbit anti-Human, Mouse Bcl-6 Polyclonal Antibody | anti-Bcl-6 antibody
Bcl-6 Polyclonal Antibody
Aliquot store at -20 degree C or -80 degree C.
Avoid repeated freeze/thaw cycles.
Western Blot (WB)
(Western Blot analysis of Bcl-6 on NIH-3T3 cell lysate using anti-Bcl-6 antibody at 1/500 dilution.)
Western Blot (WB)
(Western Blot analysis of Bcl-6 on NIH-3T3 cell lysate using anti-Bcl-6 antibody at 1/500 dilution.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Description
Bcl-6: a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL.
Protein type: C2H2-type zinc finger protein; Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 3q27
Cellular Component: replication fork; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; chromatin DNA binding; metal ion binding; chromatin binding; transcription factor activity
Biological Process: erythrocyte development; positive regulation of apoptosis; regulation of memory T cell differentiation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; Rho protein signal transduction; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; positive regulation of histone deacetylation; positive regulation of B cell proliferation; germinal center formation; negative regulation of mast cell cytokine production; inflammatory response; negative regulation of T-helper 2 cell differentiation; regulation of immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of cell motility; negative regulation of cell-matrix adhesion; regulation of germinal center formation; negative regulation of Rho protein signal transduction; protein import into nucleus, translocation; B cell differentiation; regulation of inflammatory response; negative regulation of Notch signaling pathway; spermatogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; actin cytoskeleton organization and biogenesis; response to DNA damage stimulus; negative regulation of B cell apoptosis
Research Articles on Bcl-6
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Product Notes
The Bcl-6 bcl6 (Catalog #AAA3012303) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Bcl-6 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Bcl-6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1,000-1:5,000. Researchers should empirically determine the suitability of the Bcl-6 bcl6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bcl-6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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