Rabbit anti-Human bcl 10 (CipER, CLAP) Polyclonal Antibody | anti-BCL10 antibody

bcl 10 (NT) (CipER, CLAP)

Cat. Num. AAA395915

• Gene Names: BCL10; CLAP; mE10; CIPER; c-E10; CARMEN
• Reactivity: Human
• Applications: Western Blot
• Purity: Antigen Immunoaffiinity Purification
• Synonyms: bcl 10 (CipER; CLAP); Polyclonal Antibody; bcl 10 (NT) (CipER; CIPER; mE10; CARMEN; CLAP; anti-BCL10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Immunoaffiinity Purification
• Form/Format: Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative
• Sequence Length: 233

• Applicable Applications for anti-BCL10 antibody: Western Blot (WB)
• Immunogen: Synthetic peptide corresponding to amino acids 5 to 19 of the human BCL-10 protein.
• Positive Control: Raji whole cell lysate
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Western Blot/Blotting

(Western blot analysis)

Related Product Information for anti-BCL10 antibody

Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP (1-6). Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF- B activation (1,2,4,6). Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing (3) and induces apoptosis through caspase-9 activation (3.6). BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy (1,5). BCL10 is expressed in many human and murine tissues and cell lines (2-6).

Product Categories/Family for anti-BCL10 antibody

Polyclonal Antibody; Bcl-2 Family

NCBI and Uniprot Product Information

• NCBI GI #: 4502379
• NCBI GeneID: 8915
• NCBI Accession #: NP_003912.1
• NCBI GenBank Nucleotide #: NM_003921.4
• UniProt Accession #: O95999; Q5VUF1
• Molecular Weight: 31
• NCBI Official Full Name: B-cell lymphoma/leukemia 10
• NCBI Official Synonym Full Names: B-cell CLL/lymphoma 10
• NCBI Official Symbol: BCL10
• NCBI Official Synonym Symbols: CLAP; mE10; CIPER; c-E10; CARMEN
• NCBI Protein Information: B-cell lymphoma/leukemia 10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator
• UniProt Protein Name: B-cell lymphoma/leukemia 10
• Protein Family: B-cell lymphoma/leukemia
• UniProt Gene Name: BCL10
• UniProt Synonym Gene Names: CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10
• UniProt Entry Name: BCL10_HUMAN

NCBI Description

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. Ref.15

Subunit structure: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive

By similarity. Ref.13

Subcellular location: Cytoplasm › perinuclear region. Membrane raft. Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. Ref.13

Tissue specificity: Ubiquitous.

Post-translational modification: Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB. Ref.12 Ref.14

Involvement in disease: A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.Defects in BCL10 are involved in various types of cancer.Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos.Note: The gene represented in this entry may be involved in disease pathogenesis.

Sequence similarities: Contains 1 CARD domain.