Rabbit anti-Human BBS7 Polyclonal Antibody | anti-BBS7 antibody

BBS7, NT (BBS7, BBS2L1, Bardet-Biedl syndrome 7 protein, BBS2-like protein 1) (PE)

Cat. Num. AAA6277745

• Gene Names: BBS7; BBS2L1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: BBS7; Polyclonal Antibody; NT (BBS7; BBS2L1; Bardet-Biedl syndrome 7 protein; BBS2-like protein 1) (PE); BBS2-like protein 1; anti-BBS7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-BBS7 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: BBS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-99 amino acids from the N-terminal region of human BBS7.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(BBS7 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the BBS7 antibody detected the BBS7 protein (arrow).)

Related Product Information for anti-BBS7 antibody

Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 7. The encoded protein may play a role in eye, limb, cardiac and reproductive system development. Two transcript variants encoding distinct isoforms have been identified for this gene.

Product Categories/Family for anti-BBS7 antibody

Antibodies; Disease Markers

References

Bin, J., et al. Hum. Mutat. 30 (7), E737-E746 (2009): Chung, W.K., et al. Hum. Hered. 67(3):193-205(2009). Oeffner, F., et al. Cell Motil. Cytoskeleton 65(2):143-155(2008). Yang, Z., et al. Mol. Vis. 14, 2304-2308 (2008): Nachury, M.V., et al. Cell 129(6):1201-1213(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 29029557
• NCBI GeneID: 55212
• NCBI Accession #: NP_789794.1; NP_060660.2
• NCBI GenBank Nucleotide #: NM_176824.2
• UniProt Accession #: Q8IWZ6; Q4W5P8; Q8N581; Q9NVI4
• Molecular Weight: 75,446 Da
• NCBI Official Full Name: Bardet-Biedl syndrome 7 protein isoform a
• NCBI Official Synonym Full Names: Bardet-Biedl syndrome 7
• NCBI Official Symbol: BBS7
• NCBI Official Synonym Symbols: BBS2L1
• NCBI Protein Information: Bardet-Biedl syndrome 7 protein
• UniProt Protein Name: Bardet-Biedl syndrome 7 protein
• Protein Family: Bardet-Biedl syndrome 7 protein
• UniProt Gene Name: BBS7
• UniProt Synonym Gene Names: BBS2L1
• UniProt Entry Name: BBS7_HUMAN

NCBI Description

This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Oct 2014]