Mouse anti-Human, Mouse BBS12 Polyclonal Antibody | anti-BBS12 antibody

BBS12 (Bardet-Biedl Syndrome 12 Protein, C4orf24, FLJ35630, FLJ41559)

Cat. Num. AAA6001908

• Gene Names: BBS12; C4orf24
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: BBS12; Polyclonal Antibody; BBS12 (Bardet-Biedl Syndrome 12 Protein; C4orf24; FLJ35630; FLJ41559); Anti -BBS12 (Bardet-Biedl Syndrome 12 Protein; anti-BBS12 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human BBS12. Species Crossreactivity: mouse.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MVMACRVVNKRRHMGLQQLSSFAETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESLDLTSAVGQLLNEAVQAQNNTYRTGISTLLFLVGAWSSAVEECLHLGVPISIIVSVMSEGLNFCSEEVVSLHVPVHNIFDCMDSTKTFSQLETFSVSLCPFLQVPSDTDLIEELHGLKDVASQTLTISNLSGRPLKSYELFKPQTKVEADNNTSRTLKNSLLADTCCRQSILIHSRHFNRTDNTEGVSKPDGFQEHVTATHKTYRCNDLVELAVGLSHGDHSSMKLVEEAVQLQYQNACVQQGNCTKPFMFDISRIFTCCLPGLPETSSCVCPGYITVVSVSNNPVIKELQNQPVRIVLIEGDLTENYRHLGFNKSANIKTVLDSMRLQEDSSEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVMQAFAEAAGAVQVAYITQVNEDCVGDGVCVTFWRSSPLDVVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFWTCAYRLYYALKEEKVFLGGGAVEFLCLSCLHILAEQSLKKENHACSGWLHNTSSWLASSLAIYRPTVLKFLANGWQKYLSTLLYNTANYSSEFEASTYIQHHLQNATDSGSPSSYILNEYSKLNSRIFNSDISNKLEQIPRVYDVVTPKIEAWRRALDLVLLVLQTDSEIITGHGHTQINSQELTGFLFL

• Applicable Applications for anti-BBS12 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human BBS12, aa1-710 (NP_689831.2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FLJ35630 polyclonal antibody. Western Blot analysis of FLJ35630 expression in Y-79.)

Western Blot (WB)

(BBS12 polyclonal antibody. Western Blot analysis of BBS12 expression in NIH/3T3.)

Western Blot (WB)

(Western Blot analysis of BBS12 expression in transfected 293T cell line by BBS12 polyclonal antibody. Lane 1: FLJ35630 transfected lysate (78.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-BBS12 antibody

Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.

Product Categories/Family for anti-BBS12 antibody

Antibodies; Abs to Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 295821198
• NCBI GeneID: 166379
• NCBI Accession #: NP_001171478.1
• NCBI GenBank Nucleotide #: NM_001178007.1
• UniProt Accession #: Q6ZW61; Q7Z342; Q7Z482; Q8NAB8; D3DNX5
• Molecular Weight: 79,085 Da
• NCBI Official Full Name: Bardet-Biedl syndrome 12 protein
• NCBI Official Synonym Full Names: Bardet-Biedl syndrome 12
• NCBI Official Symbol: BBS12
• NCBI Official Synonym Symbols: C4orf24
• NCBI Protein Information: Bardet-Biedl syndrome 12 protein
• UniProt Protein Name: Bardet-Biedl syndrome 12 protein
• Protein Family: Bardet-Biedl syndrome 12 protein
• UniProt Gene Name: BBS12
• UniProt Synonym Gene Names: C4orf24
• UniProt Entry Name: BBS12_HUMAN

NCBI Description

The protein encoded by this gene is part of a complex that is involved in membrane trafficking. The encoded protein is a molecular chaperone that aids in protein folding upon ATP hydrolysis. This protein also plays a role in adipocyte differentiation. Defects in this gene are a cause of Bardet-Biedl syndrome type 12. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

BBS12: Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. Defects in BBS12 are the cause of Bardet-Biedl syndrome type 12 (BBS12). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect. BBS12 seems to be rarely involved in oligogenic inheritance. Belongs to the TCP-1 chaperonin family. BBS12 subfamily.

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: cilium

Molecular Function: protein binding; ATP binding

Biological Process: cellular protein metabolic process; eating behavior; photoreceptor cell maintenance; intraflagellar transport; chaperone-mediated protein complex assembly; negative regulation of fat cell differentiation

Disease: Bardet-biedl Syndrome 12