Rabbit anti-Human BATF3 Polyclonal Antibody | anti-BATF3 antibody

BATF3 Antibody (Center)

Cat. Num. AAA9216042

• Gene Names: BATF3; JDP1; SNFT; JUNDM1
• Reactivity: Human
• Applications: Western Blot
• Synonyms: BATF3; Polyclonal Antibody; BATF3 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); Basic leucine zipper transcriptional factor ATF-like 3; B-ATF-3; 21 kDa small nuclear factor isolated from T-cells; Jun dimerization protein p21SNFT; SNFT; anti-BATF3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This BATF3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 58-89 amino acids from the Central region of human BATF3.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 127

• Applicable Applications for anti-BATF3 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-BATF3 Antibody (Center) at 1:2000 dilution + HuT78 whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 14 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-BATF3 antibody

AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.

References

Iacobelli M.,et al.J. Immunol. 165:860-868(2000). Gregory S.G.,et al.Nature 441:315-321(2006). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Bower K.E.,et al.J. Biol. Chem. 277:34967-34977(2002). Bower K.E.,et al.Oncogene 23:8805-8814(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 8924246
• NCBI GeneID: 55509
• NCBI Accession #: NP_061134.1
• NCBI GenBank Nucleotide #: NM_018664.2
• UniProt Accession #: Q9NR55
• Molecular Weight: 14468
• NCBI Official Full Name: basic leucine zipper transcriptional factor ATF-like 3
• NCBI Official Synonym Full Names: basic leucine zipper ATF-like transcription factor 3
• NCBI Official Symbol: BATF3
• NCBI Official Synonym Symbols: JDP1; SNFT; JUNDM1
• NCBI Protein Information: basic leucine zipper transcriptional factor ATF-like 3
• UniProt Protein Name: Basic leucine zipper transcriptional factor ATF-like 3
• Protein Family: Basic leucine zipper transcriptional factor
• UniProt Gene Name: BATF3
• UniProt Synonym Gene Names: SNFT; B-ATF-3
• UniProt Entry Name: BATF3_HUMAN

NCBI Description

This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

Uniprot Description

BATF3: Functions as a negative regulator of AP-1-mediated transcription by heterodimerizing with JUN and binding DNA at 12- O-tetradecanoylphorbol-13-acetate response elements (TRE) (consensus: 5'-TGA[CG]TCA-3'). Represses IL2 and MMP1 promoter activities. Belongs to the bZIP family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: nucleus

Molecular Function: protein binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; response to virus; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter