Rabbit anti-Human BAG5 Polyclonal Antibody | anti-BAG5 antibody

BAG5 Antibody

Cat. Num. AAA9404553

• Gene Names: BAG5; BAG-5
• Reactivity: Human
• Applications: ELISA, Western Blot
• Synonyms: BAG5; Polyclonal Antibody; BAG5 Antibody; Bcl-2-associated athanogene 5; anti-BAG5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total BAG5 protein.
• Form/Format: Supplied at 0.3mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
• Sequence Length: 1859

• Applicable Applications for anti-BAG5 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:500-1:5000; Western blotting: 1:500-1:2000
• Immunogen Type: Recombinant protein
• Immunogen Description: Fusion protein corresponding to C terminal 350 amino acids of Human Bcl-2-associated athanogene 5
• Target Name: BAG5
• Preparation and Storage: Store at -20 degree C/1 year

Testing Data

(Gel: 10%SDS-PAGELane1: A549 cell lysateLane2: Hela cell lysateLane3: 293T cell lysateLysates: 40 ug per lanePrimary antibody: 1/500 dilutionSecondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/3000 dilutionExposure time: 1 minute)

Related Product Information for anti-BAG5 antibody

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.

Product Categories/Family for anti-BAG5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 29792007
• NCBI GeneID: 9529
• Molecular Weight: 56,027 Da
• NCBI Official Full Name: Homo sapiens BCL2-associated athanogene 5, mRNA
• NCBI Official Synonym Full Names: BCL2-associated athanogene 5
• NCBI Official Symbol: BAG5
• NCBI Official Synonym Symbols: BAG-5
• NCBI Protein Information: BAG family molecular chaperone regulator 5
• UniProt Protein Name: BAG family molecular chaperone regulator 5
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: BAG5
• UniProt Synonym Gene Names: KIAA0873; BAG-5
• UniProt Entry Name: BAG5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

BAG5: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: membrane; mitochondrion; perinuclear region of cytoplasm; inclusion body; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding; chaperone binding; protein kinase binding

Biological Process: protein folding; negative regulation of ubiquitin-protein ligase activity; negative regulation of protein ubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process