Mouse anti-Human B4GALT7 Polyclonal Antibody | anti-B4GALT7 antibody

B4GALT7 (Beta-1,4-galactosyltransferase 7, Beta-1,4-GalTase 7, Beta4Gal-T7, b4Gal-T7, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7, XGALT1, UNQ748/PRO1478)

Cat. Num. AAA642947

• Gene Names: B4GALT7; EDSP1; XGPT1; XGALT1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: B4GALT7; Polyclonal Antibody; B4GALT7 (Beta-1; 4-galactosyltransferase 7; Beta-1; 4-GalTase 7; Beta4Gal-T7; b4Gal-T7; UDP-Gal:beta-GlcNAc beta-1; UDP-galactose:beta-N-acetylglucosamine beta-1; XGALT1; UNQ748/PRO1478); Anti -B4GALT7 (Beta-1; anti-B4GALT7 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human B4GALT7.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPPPEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLNEELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQLFRPSGITTGYKTFRHLHDPAWRKRDQKRIAAQKQEQFKVDREGGLNTVKYHVASRTALSVGGAPCTVLNIMLDCDKTATPWCTFS

• Applicable Applications for anti-B4GALT7 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human B4GALT7, aa1-327 (NP_009186.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of B4GALT7 expression in transfected 293T cell line by B4GALT7 polyclonal antibody. Lane 1: B4GALT7 transfected lysate (35.97kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-B4GALT7 antibody

Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.

Product Categories/Family for anti-B4GALT7 antibody

Antibodies; Abs to Enzymes; Glycosyltransferase

NCBI and Uniprot Product Information

• NCBI GI #: 37182278
• NCBI GeneID: 11285
• UniProt Accession #: Q9UBV7; Q9UHN2; B3KN39
• Molecular Weight: 37,406 Da
• NCBI Official Full Name: B4GALT7
• NCBI Official Synonym Full Names: xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
• NCBI Official Symbol: B4GALT7
• NCBI Official Synonym Symbols: EDSP1; XGPT1; XGALT1
• NCBI Protein Information: beta-1,4-galactosyltransferase 7; beta4Gal-T7; beta4GalT-VII; beta-1,4-GalTase 7; galactosyltransferase I; beta-1,4-galactosyltransferase VII; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7
• UniProt Protein Name: Beta-1,4-galactosyltransferase 7
• Protein Family: Beta-1,4-galactosyltransferase
• UniProt Gene Name: B4GALT7
• UniProt Synonym Gene Names: XGALT1; Beta-1,4-GalTase 7; Beta4Gal-T7; b4Gal-T7
• UniProt Entry Name: B4GT7_HUMAN

NCBI Description

This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. [provided by RefSeq, Oct 2009]

Uniprot Description

B4GALT7: Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. Defects in B4GALT7 are the cause of Ehlers-Danlos syndrome progeroid type (EDSP). EDSP is a variant form of Ehlers-Danlos syndrome characterized by progeroid facies, mild mental retardation, short stature, skin hyperextensibility, moderate skin fragility, joint hypermobility principally in digits. Belongs to the glycosyltransferase 7 family.

Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase; EC 2.4.1.133

Chromosomal Location of Human Ortholog: 5q35.2-q35.3

Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane

Molecular Function: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; manganese ion binding; xylosylprotein 4-beta-galactosyltransferase activity; galactosyltransferase activity

Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; proteoglycan metabolic process; glycosaminoglycan metabolic process; negative regulation of fibroblast proliferation; carbohydrate metabolic process; protein amino acid N-linked glycosylation; fibril organization and biogenesis; protein modification process; pathogenesis

Disease: Ehlers-danlos Syndrome, Progeroid Type, 1