Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human glioma using MBS1492593 at dilution 1:100)
Rabbit anti-Human B-cell lymphoma/leukemia 11A Polyclonal Antibody | anti-BCL11A antibody
Rabbit anti-human B-cell lymphoma/leukemia 11A polyclonal Antibody(BCL11A)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human glioma using MBS1492593 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human glioma using MBS1492593 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human spleen using MBS1492593 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human spleen using MBS1492593 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity
Biological Process: B cell differentiation; negative regulation of axon extension; negative regulation of collateral sprouting; negative regulation of protein homooligomerization; negative regulation of transcription from RNA polymerase II promoter; positive regulation of collateral sprouting; positive regulation of transcription from RNA polymerase II promoter; protein sumoylation; regulation of dendrite development; signal transduction; T cell differentiation; transcription from RNA polymerase II promoter
Research Articles on BCL11A
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Product Notes
The BCL11A bcl11a (Catalog #AAA1492593) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human B-cell lymphoma/leukemia 11A polyclonal Antibody(BCL11A) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's B-cell lymphoma/leukemia 11A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the BCL11A bcl11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "B-cell lymphoma/leukemia 11A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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