Rabbit AVEN / PDCD12 Polyclonal Antibody | anti-AVEN antibody

Rabbit Polyclonal to Human AVEN / PDCD12

Cat. Num. AAA240489

• Gene Names: AVEN; PDCD12
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: AVEN / PDCD12; Polyclonal Antibody; Rabbit Polyclonal to Human AVEN / PDCD12; Anti-AVEN / PDCD12 Antibody (C-Terminus) IHC-plus; AVEN; Cell death regulator Aven; Programmed cell death 12; PDCD12; Human AVEN; anti-AVEN antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: 14 amino acid peptide from near the carboxy terminus of human Aven
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 362

• Applicable Applications for anti-AVEN antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (2.5 ug/ml), WB (0.5 - 1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human AVEN.
• Immunogen Type: Synthetic peptide
• Immunogen: AVEN / PDCD12 antibody was raised against synthetic peptide from human AVEN.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-AVEN antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of AVEN in Human Spleen cells with AVEN antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of Aven in Raji cell lysate with Aven antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 9966841
• NCBI GeneID: 57099
• NCBI Accession #: NP_065104.1
• NCBI GenBank Nucleotide #: NM_020371.2
• UniProt Accession #: Q9NQS1
• Molecular Weight: 38,506 Da
• NCBI Official Full Name: cell death regulator Aven
• NCBI Official Synonym Full Names: apoptosis, caspase activation inhibitor
• NCBI Official Symbol: AVEN
• NCBI Official Synonym Symbols: PDCD12
• NCBI Protein Information: cell death regulator Aven; programmed cell death 12
• UniProt Protein Name: Cell death regulator Aven
• Protein Family: Cell death regulator
• UniProt Gene Name: AVEN
• UniProt Entry Name: AVEN_HUMAN

Uniprot Description

AVEN: Protects against apoptosis mediated by Apaf-1. Binds Apaf-1, BCL-2 and BAD (Bcl-xl). Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.

Protein type: Inhibitor; Apoptosis

Chromosomal Location of Human Ortholog: 15q13.1

Cellular Component: membrane; endomembrane system; intracellular

Molecular Function: protein binding

Biological Process: apoptosis; negative regulation of apoptosis