Testing Data
Rabbit ATXN7L3 Polyclonal Antibody | anti-ATXN7L3 antibody
ATXN7L3 Antibody
Reactivity
HumanPredicted: Mouse, Rat
Applications
ELISA, Western Blot
Synonyms
ATXN7L3; Polyclonal Antibody; ATXN7L3 Antibody; anti-ATXN7L3 antibody
Host
Rabbit
Reactivity
Human
Predicted: Mouse, Rat
Predicted: Mouse, Rat
Clonality
Polyclonal
Form/Format
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
Sequence Length
354
Applicable Applications for anti-ATXN7L3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
ELISA: 1:20,000-1:80,000
WB: 1:200-1:1,000
WB: 1:200-1:1,000
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Testing Data
Testing Data
Related Product Information for anti-ATXN7L3 antibody
Rabbit polyclonal ATXN7L3(1) antibody was raised against a recombinate human ATXN7L3 protein 2-189aa (BC113595).
References
(1) Bonnet, J., Wang, Y.H., Spedale, G., et al. The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties. EMBO Rep. 11 (8), 612-618 (2010).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,599 Da
NCBI Official Full Name
ataxin-7-like protein 3 isoform a
NCBI Official Synonym Full Names
ataxin 7 like 3
NCBI Official Symbol
ATXN7L3
NCBI Protein Information
ataxin-7-like protein 3
UniProt Protein Name
Ataxin-7-like protein 3
Protein Family
UniProt Gene Name
ATXN7L3
Uniprot Description
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).
Research Articles on ATXN7L3
Similar Products
Product Notes
The ATXN7L3 atxn7l3 (Catalog #AAA8527209) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATXN7L3 Antibody reacts with Human Predicted: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ATXN7L3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ELISA: 1:20,000-1:80,000 WB: 1:200-1:1,000. Researchers should empirically determine the suitability of the ATXN7L3 atxn7l3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATXN7L3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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