Rabbit ATXN7L2 Polyclonal Antibody | anti-ATXN7L2 antibody

ATXN7L2 Polyclonal Antibody

Cat. Num. AAA3006992

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ATXN7L2; Polyclonal Antibody; ATXN7L2 Polyclonal Antibody; Ataxin-7-like protein 2; anti-ATXN7L2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ATXN7L2 polyclonal antibody detects endogenous levels of ATXN7L2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 722

• Applicable Applications for anti-ATXN7L2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human ATXN7L2
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ATXN7L2 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264. 7 whole cell lysate Lane3:H9C2 whole cell lysate)

Related Product Information for anti-ATXN7L2 antibody

SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product. Ataxin-7 is a nuclear protein that is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype. Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function.ATXN7L2 (Ataxin-7-like protein 2) is a 722 amino acid protein that contains a SCA7 domain, which is highly conserved through all members of the ATXN7 gene family. The gene encoding ATXN7L2 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.

NCBI and Uniprot Product Information

• NCBI GI #: 93277115
• NCBI Accession #: NP_699171.3
• NCBI GenBank Nucleotide #: NP_699171.3
• UniProt Accession #: Q5T6C5
• Molecular Weight: ~ 77kDa
• NCBI Official Full Name: ataxin-7-like protein 2 isoform 2
• UniProt Protein Name: Ataxin-7-like protein 2
• Protein Family: Ataxin
• UniProt Gene Name: ATXN7L2
• UniProt Entry Name: AT7L2_HUMAN

Uniprot Description

ataxin-7L2: Belongs to the ataxin-7 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1p13.3