Rabbit anti-Human ATRIP Polyclonal Antibody | anti-ATRIP antibody

ATRIP (ATR-interacting protein)

Cat. Num. AAA618893

• Gene Names: ATRIP; FLJ12343; MGC20625; MGC21482; MGC26740; DKFZp762J2115
• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: ATRIP; Polyclonal Antibody; ATRIP (ATR-interacting protein); Anti -ATRIP (ATR-interacting protein); anti-ATRIP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human ATRIP.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Liquid. Protein G purified antibody in PBS containing 10% glycerol and 0.02% sodium azide.

• Applicable Applications for anti-ATRIP antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry.; Dilution: Western Blot: 0.75ug/ml; Immunoprecipitation: 0.1-0.5ug
• Immunogen: Recombinant human ATRIP (aa 1-182).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-ATRIP antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 18390347
• NCBI GeneID: 84126
• NCBI Accession #: NP_569055.1
• NCBI GenBank Nucleotide #: NM_130384.1
• UniProt Accession #: Q8WXE1; Q69YK9; Q8NHQ2; Q8WUG7; Q96CL3; Q9HA30; A8K6A3; A8K714; B2RCE7
• Molecular Weight: 85,838 Da
• NCBI Official Full Name: ATR-interacting protein isoform 1
• NCBI Official Synonym Full Names: ATR interacting protein
• NCBI Official Symbol: ATRIP
• NCBI Official Synonym Symbols: FLJ12343; MGC20625; MGC21482; MGC26740; DKFZp762J2115
• NCBI Protein Information: ATR-interacting protein; OTTHUMP00000164811; OTTHUMP00000164812; OTTHUMP00000210129; ATM and Rad3-related-interacting protein
• UniProt Protein Name: ATR-interacting protein
• Protein Family: ATR-interacting protein
• UniProt Gene Name: ATRIP
• UniProt Synonym Gene Names: AGS1
• UniProt Entry Name: ATRIP_HUMAN

NCBI Description

The product of this gene is an essential component of the DNA damage checkpoint, and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

ATRIP: is required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Heterodimerizes with ATR. The heterodimer binds replication protein A (RPA), a protein complex that subsequently is recruited to single stranded DNA (ssDNA). Its EEXXXDDL motif is required for the interaction with catalytic subunit of DNA-PK and its recruitment to sites of DNA damage. e for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame. Three alternatively spliced human isoforms have been reported.

Protein type: DNA-binding; DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: DNA damage checkpoint; DNA repair; DNA replication