Sheep Atrial Natriuretic Peptide, pro-, aa31-67 Polyclonal Antibody | anti-NPPA antibody

Atrial Natriuretic Peptide, pro-, aa31-67 (ANP, ANF, Atrial natriuretic factor, Atrial natriuretic factor precursor, CDD ANF, Natriuretic Peptide Precursor A, NPPA, PND, Prepronatriodilatin)

Cat. Num. AAA631143

• Gene Names: NPPA; ANF; ANP; PND; ATFB6; CDD-ANF
• Purity: Serum; Serum
• Synonyms: Atrial Natriuretic Peptide; pro-; aa31-67; Polyclonal Antibody; aa31-67 (ANP; ANF; Atrial natriuretic factor; Atrial natriuretic factor precursor; CDD ANF; Natriuretic Peptide Precursor A; NPPA; PND; Prepronatriodilatin); Anti -Atrial Natriuretic Peptide; anti-NPPA antibody

• Host: Sheep
• Clonality: Polyclonal
• Specificity: Recognizes synthetic human pro-Atrial Natriuretic Peptide (aa 31-67). There were no cross reactivities obtained with human pro-ANP (aa 67-98) and human pro-ANP (aa 1-30)
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a lyophilized powder. Reconstitute with sterile dH2O.

• Application Notes: Suitable for use in ELISA, RIA.; Dilution: RIA: 1:2000
• Immunogen: Synthetic human pro-ANP (aa 31-67) polylysine conjugated (EVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQR).
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-NPPA antibody

Antibodies; Abs to Cardiac Markers

NCBI and Uniprot Product Information

• NCBI GI #: 178638
• NCBI GeneID: 4878
• UniProt Accession #: P01160; Q13766; Q5JZE1
• Molecular Weight: 16,708 Da
• NCBI Official Full Name: atrial natriuretic peptide
• NCBI Official Synonym Full Names: natriuretic peptide A
• NCBI Official Symbol: NPPA
• NCBI Official Synonym Symbols: ANF; ANP; PND; ATFB6; CDD-ANF
• NCBI Protein Information: natriuretic peptides A; atriopeptin; cardionatrin; OTTHUMP00000002504; prepronatriodilatin; natriuretic peptide precursor A
• UniProt Protein Name: Natriuretic peptides A
• UniProt Gene Name: NPPA
• UniProt Synonym Gene Names: ANP; PND
• UniProt Entry Name: ANF_HUMAN

NCBI Description

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq]

Uniprot Description

NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.

Protein type: Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: extracellular space; mast cell granule; perinuclear region of cytoplasm; extracellular region; nucleus

Molecular Function: neuropeptide hormone activity; peptide hormone receptor binding; receptor binding

Biological Process: cardiac muscle hypertrophy; cGMP biosynthetic process; transcription initiation from RNA polymerase II promoter; neuropeptide signaling pathway; regulation of blood pressure; negative regulation of systemic arterial blood pressure; receptor guanylyl cyclase signaling pathway; response to hypoxia; positive regulation of heart rate; gene expression; negative regulation of cell growth; female pregnancy; regulation of blood vessel size; response to insulin stimulus

Disease: Atrial Standstill 2; Atrial Fibrillation, Familial, 6