Rabbit anti-Rat ATPase, H+ Transporting, Mitochondrial F1 Complex Beta Polypeptide (ATP5b) Polyclonal Antibody | anti-ATP5b antibody
Biotin-Linked Polyclonal Antibody to ATPase, H+ Transporting, Mitochondrial F1 Complex Beta Polypeptide (ATP5b)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]
Uniprot Description
ATP5B: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase alpha/beta chains family.
Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: cell surface; extracellular matrix; membrane; mitochondrial matrix; mitochondrial membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase, catalytic core; mitochondrion; myelin sheath; nucleus; plasma membrane; proton-transporting ATP synthase complex
Molecular Function: angiostatin binding; ATP binding; ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; MHC class I protein binding; protein binding; proton-transporting ATP synthase activity, rotational mechanism; transmembrane transporter activity; transporter activity
Biological Process: angiogenesis; ATP biosynthetic process; cristae formation; generation of precursor metabolites and energy; lipid metabolic process; mitochondrial ATP synthesis coupled proton transport; mitochondrion organization; negative regulation of cell adhesion involved in substrate-bound cell migration; osteoblast differentiation; positive regulation of blood vessel endothelial cell migration; proton transport; regulation of intracellular pH
