Rabbit anti-Human ATP6V1H Polyclonal Antibody | anti-ATP6V1H antibody

ATP6V1H Antibody

Cat. Num. AAA9414692

• Gene Names: ATP6V1H; SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ATP6V1H; Polyclonal Antibody; ATP6V1H Antibody; Vacuolar proton pump subunit H; EC 3.6.3.14; V-ATPase subunit H; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit SFD; anti-ATP6V1H antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ATP6V1H protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 483

• Applicable Applications for anti-ATP6V1H antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50~1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human ATP6V1H.
• Target Name: ATP6V1H
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue using ATP6V1H antibody.)

Related Product Information for anti-ATP6V1H antibody

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system By similarity. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.Liu B., Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.Lu X., Immunity 8:647-656(1998).Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).Lai C.-H., Genome Res. 10:703-713(2000).

Product Categories/Family for anti-ATP6V1H antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 47717104
• NCBI GeneID: 51606
• NCBI Accession #: NP_057025.2
• NCBI GenBank Nucleotide #: NM_015941.3
• UniProt Accession #: Q9UI12; Q6PK44; Q9H3E3; Q9Y300; B3KMR0
• Molecular Weight: 54,151 Da
• NCBI Official Full Name: V-type proton ATPase subunit H isoform 1
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
• NCBI Official Symbol: ATP6V1H
• NCBI Official Synonym Symbols: SFD; NBP1; VMA13; CGI-11; MSTP042; SFDbeta; SFDalpha
• NCBI Protein Information: V-type proton ATPase subunit H
• UniProt Protein Name: V-type proton ATPase subunit H
• Protein Family: V-type proton ATPase
• UniProt Gene Name: ATP6V1H
• UniProt Synonym Gene Names: V-ATPase subunit H; NBP1
• UniProt Entry Name: VATH_HUMAN

NCBI Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Description

ATP6V1H: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. Belongs to the V-ATPase H subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Energy Metabolism - oxidative phosphorylation; Hydrolase; EC 3.6.3.14

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: lysosomal membrane; plasma membrane; cytosol; vacuolar proton-transporting V-type ATPase, V1 domain

Molecular Function: protein binding; ATPase activity; hydrogen ion transporting ATPase activity, rotational mechanism; enzyme regulator activity

Biological Process: vacuolar acidification; interaction with host; viral reproduction; regulation of catalytic activity; cellular iron ion homeostasis; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; endocytosis; transmembrane transport; regulation of defense response to virus by virus