Western Blot (WB)
(Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide)
Rabbit anti-Human, Mouse ATP2C2 Polyclonal Antibody | anti-ATP2C2 antibody
ATP2C2 Antibody
Gene Names
ATP2C2; SPCA2
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
ATP2C2; Polyclonal Antibody; ATP2C2 Antibody; Calcium-transporting ATPase type 2C member 2; PMR1; SPCA2; hSPCA2; anti-ATP2C2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
946
Applicable Applications for anti-ATP2C2 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide near the amino terminus of human ATP2C2.
Target Name
ATP2C2
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide)
Western Blot (WB)
(Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide)
Related Product Information for anti-ATP2C2 antibody
ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
Product Categories/Family for anti-ATP2C2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
106,235 Da
NCBI Official Full Name
calcium-transporting ATPase type 2C member 2 isoform 2
NCBI Official Synonym Full Names
ATPase, Ca++ transporting, type 2C, member 2
NCBI Official Symbol
ATP2C2
NCBI Official Synonym Symbols
SPCA2
NCBI Protein Information
calcium-transporting ATPase type 2C member 2
UniProt Protein Name
Calcium-transporting ATPase type 2C member 2
Protein Family
UniProt Gene Name
ATP2C2
UniProt Synonym Gene Names
KIAA0703; SPCA2; ATPase 2C2
UniProt Entry Name
AT2C2_HUMAN
Uniprot Description
ATP2C2: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Transporter; EC 3.6.3.8; Membrane protein, integral; Hydrolase; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: protein binding; calcium-transporting ATPase activity; metal ion binding; ATP binding
Biological Process: metabolic process; transmembrane transport
Research Articles on ATP2C2
Similar Products
Product Notes
The ATP2C2 atp2c2 (Catalog #AAA9409672) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATP2C2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ATP2C2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the ATP2C2 atp2c2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATP2C2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
