Rabbit anti-Human ATP2A2 Polyclonal Antibody | anti-ATP2A2 antibody

ATP2A2, ID (ATP2A2, ATP2B, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, Endoplasmic reticulum class 1/2 Ca(2+) ATPase) (APC)

Cat. Num. AAA6276448

• Gene Names: ATP2A2; DD; DAR; ATP2B; SERCA2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ATP2A2; Polyclonal Antibody; ID (ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type; slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase) (APC); Endoplasmic reticulum class 1/2 Ca(2+) ATPase; anti-ATP2A2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-ATP2A2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ATP2A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-403 amino acids from the Central region of human ATP2A2.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(ATP2A2 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ATP2A2 antibody detected the ATP2A2 protein (arrow).)

Related Product Information for anti-ATP2A2 antibody

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Product Categories/Family for anti-ATP2A2 antibody

Antibodies; Ion Channel

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Tuusa, J.T., et al. FEBS J. 277(13):2815-2829(2010). Godic, A., et al. Eur J Dermatol 20(3):271-275(2010). Godic, A., et al. J. Am. Acad. Dermatol. 62(5):819-823(2010). Kiec-Wilk, B., et al. Prz. Lek. 67(3):151-156(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 4502285
• NCBI GeneID: 488
• NCBI Accession #: NP_001672.1; NP_001129237.1
• NCBI GenBank Nucleotide #: NM_001681.3
• UniProt Accession #: P16615; P16614; Q86VJ2; A6NDN7; B4DF05
• Molecular Weight: 1042
• NCBI Official Full Name: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
• NCBI Official Synonym Full Names: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
• NCBI Official Symbol: ATP2A2
• NCBI Official Synonym Symbols: DD; DAR; ATP2B; SERCA2
• NCBI Protein Information: sarcoplasmic/endoplasmic reticulum calcium ATPase 2; calcium pump 2; SR Ca(2+)-ATPase 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; calcium-transporting ATPase sarcoplasmic re
• UniProt Protein Name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
• Protein Family: Sarcoplasmic/endoplasmic reticulum calcium ATPase
• UniProt Gene Name: ATP2A2
• UniProt Synonym Gene Names: ATP2B; SERCA2
• UniProt Entry Name: AT2A2_HUMAN