Western Blot (WB)
(Western blot analysis ATM (Phospho-Ser1987) using HeLa whole cell lysates)
Rabbit anti-Mouse ATM Polyclonal Antibody | anti-ATM antibody
ATM (Phospho-Ser1987) Antibody
Western Blot (WB)
(Western blot analysis ATM (Phospho-Ser1987) using HeLa whole cell lysates)
Western Blot (WB)
(Western blot analysis ATM (Phospho-Ser1987) using HeLa whole cell lysates)
NCBI and Uniprot Product Information
Uniprot Description
ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.
Protein type: ATYPICAL group; DNA repair, damage; EC 2.7.11.1; Kinase, protein; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor
Cellular Component: chromosome, telomeric region; cytoplasm; nucleus; spindle
Molecular Function: 1-phosphatidylinositol-3-kinase activity; DNA-dependent protein kinase activity; protein binding; protein complex binding; protein dimerization activity; protein kinase activity; protein N-terminus binding; protein serine/threonine kinase activity
Biological Process: brain development; cell cycle arrest; determination of adult life span; DNA damage checkpoint; DNA damage induced protein phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; DNA repair; double-strand break repair via homologous recombination; female gamete generation; female gonad development; female meiosis; heart development; immune system process; immunoglobulin production; lipoprotein catabolic process; male meiosis; mitotic cell cycle spindle assembly checkpoint; multicellular organism growth; negative regulation of B cell proliferation; neuron apoptosis; oocyte development; ovarian follicle development; peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of histone phosphorylation; positive regulation of neuron apoptosis; positive regulation of telomere maintenance via telomerase; post-embryonic development; pre-B cell allelic exclusion; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of autophagy; regulation of cell cycle; response to DNA damage stimulus; response to hypoxia; response to ionizing radiation; somitogenesis; telomere clustering; telomere maintenance via telomerase; thymus development; V(D)J recombination
Research Articles on ATM
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Product Notes
The ATM atm (Catalog #AAA9416789) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATM (Phospho-Ser1987) Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ATM can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000. Researchers should empirically determine the suitability of the ATM atm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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