Rabbit ATG7 autophagy related 7 homolog Polyclonal Antibody | anti-ATG7 antibody

Rabbit anti-human ATG7 autophagy related 7 homolog (S. cerevisiae) polyclonal Antibody

Gene Names

ATG7; GSA7; APG7L; APG7-LIKE

Reactivity

Human, Mouse, Rat

Applications

ELISA, Western Blot

Purity

Antigen Affinity Purified

Synonyms

ATG7 autophagy related 7 homolog; Polyclonal Antibody; Rabbit anti-human ATG7 autophagy related 7 homolog (S. cerevisiae) polyclonal Antibody; ATG7 autophagy related 7 homolog (S. cerevisiae); ATG7; APG7-LIKE; APG7L; DKFZp434N0735; GSA7; anti-ATG7 antibody

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Cat. Num. AAA713003 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Isotype

IgG

Purity/Purification

Antigen Affinity Purified

Sequence Length

695

Applicable Applications for anti-ATG7 antibody

ELISA (EIA), Western Blot (WB)

Immunogen

Human ATG7

Storage Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8668 / sc-12497 / sc-33211

NCBI and Uniprot Product Information

NCBI GI #

119584501

NCBI GeneID

10533

Molecular Weight

68,618 Da

NCBI Official Full Name

ATG7 autophagy related 7 homolog (S. cerevisiae), isoform CRA_b

NCBI Official Synonym Full Names

autophagy related 7

NCBI Official Symbol

ATG7

NCBI Official Synonym Symbols

GSA7; APG7L; APG7-LIKE

NCBI Protein Information

ubiquitin-like modifier-activating enzyme ATG7; hAGP7; autophagy-related protein 7; ATG12-activating enzyme E1 ATG7; ATG7 autophagy related 7 homolog; ubiquitin activating enzyme E1-like protein; ubiquitin-activating enzyme E1-like protein

UniProt Protein Name

Ubiquitin-like modifier-activating enzyme ATG7

Protein Family

Ubiquitin-like modifier-activating enzyme

UniProt Gene Name

ATG7

UniProt Synonym Gene Names

APG7L; APG7-like; hAGP7

UniProt Entry Name

ATG7_HUMAN

NCBI Description

This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]

Uniprot Description

ATG7: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; axoneme; cytosol

Molecular Function: protein binding; protein homodimerization activity; APG8 activating enzyme activity; APG12 activating enzyme activity; ubiquitin activating enzyme activity; transcription factor binding

Biological Process: regulation of protein ubiquitination; positive regulation of apoptosis; protein ubiquitination; pyramidal neuron development; adult walking behavior; post-embryonic development; protein transport; cardiac muscle cell development; protein amino acid lipidation; protein catabolic process; positive regulation of autophagy; amino acid metabolic process; central nervous system neuron axonogenesis; cerebellar Purkinje cell layer development; protein modification process; C-terminal protein lipidation; liver development; cellular response to starvation; cellular response to nitrogen starvation; neurological system process; protein modification by small protein conjugation; mitochondrion degradation; positive regulation of protein catabolic process; positive regulation of protein modification process; cerebral cortex development; positive regulation of macroautophagy; negative regulation of apoptosis

Research Articles on ATG7

1. the Atg7.caspase-9 complex performs a dual function of linking caspase-9 to the autophagic process while keeping in check its apoptotic activity.

Similar Products

ATG7 Antibody

Host: Mouse

Reactivity: Human, Mouse, Rat

Apps: Immunohistochemistry, Immunofluorescence

Product Notes

The ATG7 atg7 (Catalog #AAA713003) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human ATG7 autophagy related 7 homolog (S. cerevisiae) polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ATG7 autophagy related 7 homolog can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the ATG7 atg7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATG7 autophagy related 7 homolog, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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