Rabbit anti-Human ATG4D Polyclonal Antibody | anti-ATG4D antibody

ATG4D Antibody

Cat. Num. AAA9413960

• Gene Names: ATG4D; APG4D; AUTL4; APG4-D
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: ATG4D; Polyclonal Antibody; ATG4D Antibody; APG4D; AUTL4; APG4-D; anti-ATG4D antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ATG4D protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.7 mg/ml (varies by lot)
• Sequence Length: 411

• Applicable Applications for anti-ATG4D antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Full length fusion protein
• Target Name: ATG4D
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/40.)

Related Product Information for anti-ATG4D antibody

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes.

Product Categories/Family for anti-ATG4D antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 528078306
• NCBI GeneID: 84971
• NCBI Accession #: NP_001268433.1
• NCBI GenBank Nucleotide #: NM_001281504.1
• UniProt Accession #: Q86TL0; Q969K0
• Molecular Weight: 16,008 Da
• NCBI Official Full Name: cysteine protease ATG4D isoform 2
• NCBI Official Synonym Full Names: autophagy related 4D, cysteine peptidase
• NCBI Official Symbol: ATG4D
• NCBI Official Synonym Symbols: APG4D; AUTL4; APG4-D
• NCBI Protein Information: cysteine protease ATG4D
• UniProt Protein Name: Cysteine protease ATG4D
• Protein Family: Cysteine protease
• UniProt Gene Name: ATG4D
• UniProt Synonym Gene Names: APG4D; AUTL4
• UniProt Entry Name: ATG4D_HUMAN

NCBI Description

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

ATG4D: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Belongs to the peptidase C54 family.

Protein type: Ubiquitin conjugating system; Autophagy; Protease; EC 3.4.22.-

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: mitochondrial matrix; cytoplasm; cytosol

Molecular Function: cysteine-type endopeptidase activity

Biological Process: protein delipidation; apoptosis; mitochondrion degradation; protein processing; C-terminal protein lipidation; protein targeting to membrane; proteolysis; autophagic vacuole formation; cellular response to nitrogen starvation