Rabbit ATF6 Polyclonal Antibody | anti-ATF6 antibody

ATF6 Polyclonal Antibody

Cat. Num. AAA2556179

• Gene Names: ATF6; ACHM7; ATF6A
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: ATF6; Polyclonal Antibody; ATF6 Polyclonal Antibody; Activating Transcription Factor 6; CAMP-Dependent Transcription Factor ATF-6 Alpha; Activating Transcription Factor 6 Alpha; Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha; ATF6-Alpha; ACHM7; ATF6A.; anti-ATF6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 670

• Applicable Applications for anti-ATF6 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:1000
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse ATF6
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human lung cancer using ATF6 Polyclonal Antibody at dilution of 1:400.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human Endometrial cancer using ATF6 Polyclonal Antibody at dilution of 1:400.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded mouse heart using ATF6 Polyclonal Antibody at dilution of 1:400.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded rat lung using ATF6 Polyclonal Antibody at dilution of 1:400.)

Related Product Information for anti-ATF6 antibody

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Product Categories/Family for anti-ATF6 antibody

Cancer; Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 56786157
• NCBI GeneID: 22926
• NCBI Accession #: NP_031374.2
• NCBI GenBank Nucleotide #: NM_007348.4
• UniProt Accession #: P18850; O15139; Q5VW62; Q6IPB5; Q9UEC9
• Molecular Weight: 74,585 Da
• NCBI Official Full Name: cyclic AMP-dependent transcription factor ATF-6 alpha
• NCBI Official Synonym Full Names: activating transcription factor 6
• NCBI Official Symbol: ATF6
• NCBI Official Synonym Symbols: ACHM7; ATF6A
• NCBI Protein Information: cyclic AMP-dependent transcription factor ATF-6 alpha
• UniProt Protein Name: Cyclic AMP-dependent transcription factor ATF-6 alpha
• Protein Family: Cyclic AMP-dependent transcription factor
• UniProt Gene Name: ATF6
• UniProt Synonym Gene Names: cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha

NCBI Description

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

Uniprot Description

Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.