Western Blot (WB)
(ASPSCR1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow).)
Rabbit anti-Human ASPSCR1 Polyclonal Antibody | anti-ASPSCR1 antibody
ASPSCR1 Antibody (N-term)
Western Blot (WB)
(ASPSCR1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow).)
Western Blot (WB)
(ASPSCR1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow).)
Western Blot (WB)
(Western blot analysis of ASPSCR1 (arrow) using rabbit polyclonal ASPSCR1 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene.)
Western Blot (WB)
(Western blot analysis of ASPSCR1 (arrow) using rabbit polyclonal ASPSCR1 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene.)
sarcoma (ASPS). It has been found that this gene is fused with
transcription factor TFE3 gene in ASPS and also in renal cell
carcinomas. Several alternatively spliced transcript variants of
this gene have been described, but their full length nature has not
been determined.
Alexandru, G., et al. Cell 134(5):804-816(2008)
Vistica, D.T., et al. J. Pediatr. Hematol. Oncol. 30(1):46-52(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Bogan, J.S., et al. Nature 425(6959):727-733(2003)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
Uniprot Description
ASPSCR1: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Membrane protein, peripheral; Oncoprotein
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; ER-Golgi intermediate compartment membrane; internal side of plasma membrane; extrinsic to membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; endomembrane system; vesicle membrane; cytosol
Molecular Function: protein binding
Biological Process: intracellular protein transport; regulation of glucose import; glucose homeostasis
Disease: Alveolar Soft Part Sarcoma
Research Articles on ASPSCR1
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Product Notes
The ASPSCR1 aspscr1 (Catalog #AAA9211821) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 65-93. The ASPSCR1 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ASPSCR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ASPSCR1 aspscr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASPSCR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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