Rabbit ASB7 Polyclonal Antibody | anti-ASB7 antibody

ASB7 Antibody (Center)

Cat. Num. AAA9213255

• Reactivity: Human (Predicted Reactivity: Monkey, Mouse)
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: ASB7; Polyclonal Antibody; ASB7 Antibody (Center); Ankyrin repeat and SOCS box protein 7; ASB-7; anti-ASB7 antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Monkey, Mouse)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This ASB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the Central region of human ASB7.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.34 (varies by lot)
• Sequence Positions: 82-108
• Sequence Length: 274

• Applicable Applications for anti-ASB7 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(ASB7 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ASB7 antibody detected the ASB7 protein (arrow).)

Related Product Information for anti-ASB7 antibody

The protein encoded by this gene belongs to a family of
ankyrin repeat proteins that, along with four other protein
families, contains a C-terminal SOCS box motif. Growing evidence
suggests that the SOCS box acts as a bridge between specific
substrate-binding domains and the more generic proteins that
comprise a large family of E3 ubiquitin protein ligases. In this
way, SOCS box containing proteins may regulate protein turnover by
targeting proteins for polyubiquination and, therefore, for
proteasome-mediated degradation. Two alternative transcripts
encoding different isoforms have been described. [provided by
RefSeq].

Product Categories/Family for anti-ASB7 antibody

Cell Biology

References

Lamesch, P., et al. Genomics 89(3):307-315(2007)
Fu, G.K., et al. Genomics 84(1):205-210(2004)
Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)

NCBI and Uniprot Product Information

• NCBI GI #: 30089994
• NCBI GeneID: 140460
• NCBI Accession #: NP_078984.2; NP_937886.1
• NCBI GenBank Nucleotide #: NM_024708.3
• UniProt Accession #: Q9H672; Q6GSJ6; Q7Z4S3; A8K1E5
• Molecular Weight: 36011
• NCBI Official Full Name: ankyrin repeat and SOCS box protein 7 isoform 1
• NCBI Official Synonym Full Names: ankyrin repeat and SOCS box containing 7
• NCBI Official Symbol: ASB7
• NCBI Protein Information: ankyrin repeat and SOCS box protein 7
• UniProt Protein Name: Ankyrin repeat and SOCS box protein 7
• Protein Family: Ankyrin repeat and SOCS box protein
• UniProt Gene Name: ASB7
• UniProt Synonym Gene Names: ASB-7
• UniProt Entry Name: ASB7_HUMAN

NCBI Description

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

ASB7: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 15q26.3

Biological Process: protein ubiquitination