Western Blot (WB)
(ASB4 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ASB4 antibody detected the ASB4 protein (arrow).)
Rabbit anti-Human ASB4 Polyclonal Antibody | anti-ASB4 antibody
ASB4 Antibody (C-term)
Western Blot (WB)
(ASB4 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ASB4 antibody detected the ASB4 protein (arrow).)
Western Blot (WB)
(ASB4 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ASB4 antibody detected the ASB4 protein (arrow).)
Immunohistochemistry (IHC)
(ASB4 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human ovarian carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ASB4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(ASB4 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human ovarian carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ASB4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
ankyrin repeat and SOCS box-containing (ASB) family of proteins.
They contain ankyrin repeat sequence and SOCS box domain. The SOCS
box serves to couple suppressor of cytokine signalling (SOCS)
proteins and their binding partners with the elongin B and C
complex, possibly targeting them for degradation. Multiple
alternatively spliced transcript variants have been described for
this gene but some of the full length sequences are not known.
Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
Kile, B.T., et al. Gene 258 (1-2), 31-41 (2000) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
Uniprot Description
ASB4: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 7q21-q22
Cellular Component: Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex
Molecular Function: ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: protein autoubiquitination
Research Articles on ASB4
Similar Products
Product Notes
The ASB4 asb4 (Catalog #AAA9208685) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 226-255. The ASB4 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ASB4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the ASB4 asb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASB4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
