Rabbit anti-Human ART1 Polyclonal Antibody | anti-ART1 antibody

ART1 Polyclonal Antibody

Cat. Num. AAA3015265

• Gene Names: ART1; RT6; ART2; ARTC1; CD296
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: affinity purified by Protein A
• Synonyms: ART1; Polyclonal Antibody; ART1 Polyclonal Antibody; ART 1; FLJ17158; FLJ97586; MGC22455; Pan hematopoietic expression; PHEMX; PHMX; tetraspanin 32; Tetraspanin; tetraspanin32; TSPAN32; TSSC6; Tumor suppressing STF cDNA 6; Tumor suppressing subchromosomal transferable fragment cDNA 6; Tumor suppressing subtransferable candidate 6. ; anti-ART1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: ART1 Polyclonal Antibody detects endogenous levels of ART1 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-ART1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:100-500
• Immunogen: KLH conjugated synthetic peptide derived from human PHEMX/ART1:101-200/320
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ART1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C)

Related Product Information for anti-ART1 antibody

Phemx is a member of the tetraspanin (TM4SF) family of proteins that may be involved in transmembrane signal transduction, regulation of cell proliferation, differentiation and motility. Phemx is a multi-pass membrane protein containing intracellular N- and C-terminal domains, four transmembrane domains and two extracellular loops. It is ubiquitously expressed from early embryogenesis through adulthood. Phemx exhibits predominant expression in hematopoietic tissues suggesting a role in hematopoietic-cell function. In association with the Integrin alphaIIb/Integrin beta3 complex, Phemx functions to stabilize arterial thrombi in platelets and regulate "outside-in" signaling. This interaction may be important in the process of wound healing. The gene encoding Phemx is located in an important tumor-suppressor gene region that has been associated with Beckwith-Wiedemann syndrome as well as a variety of cancers

NCBI and Uniprot Product Information

• NCBI GI #: 158634472
• NCBI GeneID: 417
• NCBI Accession #: NP_004305.2
• NCBI GenBank Nucleotide #: NM_004314.2
• UniProt Accession #: P52961; Q6NTD2; Q96KT9
• Molecular Weight: 36,335 Da
• NCBI Official Full Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
• NCBI Official Synonym Full Names: ADP-ribosyltransferase 1
• NCBI Official Symbol: ART1
• NCBI Official Synonym Symbols: RT6; ART2; ARTC1; CD296
• NCBI Protein Information: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
• UniProt Protein Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
• Protein Family: Arrestin family protein
• UniProt Gene Name: ART1
• UniProt Synonym Gene Names: ARTC1

NCBI Description

ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

Uniprot Description

Has ADP-ribosyltransferase activity toward GLP1R.