Goat ARMS2 Polyclonal Antibody | anti-ARMS2 antibody

Goat anti-ARMS2 Antibody

Cat. Num. AAA422328

• Gene Names: ARMS2; ARMD8
• Reactivity: Tested: Human (Expected from sequence similarity: Human)
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Synonyms: ARMS2; Polyclonal Antibody; Goat anti-ARMS2 Antibody; age-related maculopathy susceptibility 2; ARMD8; age-related maculopathy susceptibility 2 antibody; ARMD8 antibody; ARMS2 antibody; anti-ARMS2 antibody

• Host: Goat
• Reactivity: Tested: Human (Expected from sequence similarity: Human)
• Clonality: Polyclonal
• Purity/Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Form/Format: Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Sequence: EGASDKQRSK
• Sequence Length: 107

• Applicable Applications for anti-ARMS2 antibody: Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: EIA (peptide): antibody detection limit dilution 1:4000.; WB: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as small as the calculated size of 11.4kDa according to NP_001093137.1. Therefore we cannot recommend an optimal concentration.; IHC: In paraffin embedded Human Retina shows cytoplasm staining throughout. Recommended concentration: 2-4µg/ml.
• Immunogen: Peptide with sequence C-EGASDKQRSK, from the internal region of the protein sequence according to NP_001093137.1.
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(MBS422328 (4µg/ml) staining of paraffin embedded Human Retina. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.)

Immunohistochemistry (IHC)

(MBS422328 Negative Control showing staining of paraffin embedded Human Retina, with no primary antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 153792797
• NCBI GeneID: 387715
• NCBI Accession #: NP_001093137.1
• NCBI GenBank Nucleotide #: NM_001099667.1
• NCBI Official Full Name: age-related maculopathy susceptibility protein 2
• NCBI Official Synonym Full Names: age-related maculopathy susceptibility 2
• NCBI Official Symbol: ARMS2
• NCBI Official Synonym Symbols: ARMD8
• NCBI Protein Information: age-related maculopathy susceptibility protein 2
• UniProt Protein Name: Age-related maculopathy susceptibility protein 2
• Protein Family: Age-related maculopathy susceptibility protein
• UniProt Gene Name: ARMS2
• UniProt Entry Name: ARMS2_HUMAN

NCBI Description

This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 2008]

Uniprot Description

ARMS2: Defects in ARMS2 influence susceptibility to age-related macular degeneration type 8 (ARMD8). ARMD is the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role.

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: mitochondrion; photoreceptor inner segment

Biological Process: retinal homeostasis

Disease: Macular Degeneration, Age-related, 8