Rabbit anti-Human ARMCX3 Polyclonal Antibody | anti-ARMCX3 antibody

ARMCX3 polyclonal antibody

Cat. Num. AAA3000193

• Gene Names: ARMCX3; ALEX3; dJ545K15.2
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ARMCX3; Polyclonal Antibody; ARMCX3 polyclonal antibody; Armadillo repeat-containing X-linked protein 3; ARM protein lost in epithelial cancers on chromosome X 3; Protein ALEX3; ALEX3; BM-017; UNQ2517/PRO6007; anti-ARMCX3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ARMCX3 polyclonal antibody detects endogenous levels of ARMCX3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

• Applicable Applications for anti-ARMCX3 antibody: Western Blot (WB)
• Application Notes: WB: 1:500~1:1000
• Immunogen: Synthetic peptide, corresponding to Human ARMCX3.
• Preparation and Storage: Store at 4 degee C for short term. Aliquot and store at -20 degee C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of ARMCX3 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysate(40ug)Lane2:Pancl whole cell lysate(40ug)Lane3:U-87MG whole cell lysate(40ug))

Related Product Information for anti-ARMCX3 antibody

Background: The armadillo (ARM) repeat family of proteins are related to the Drosophilamelanogaster armadillo protein, a protein essential for wingless signal transduction. ARM proteins are involved in a variety of processes such as cellmigration, cell proliferation, tissue maintenance and tumorigenesis. They areintracellular proteins and function in signal transduction and cell structure.ARMCX3 (armadillo repeat containing, X-linked 3), also known as ALEX3(ARM protein lost in epithelial cancers on chromosome X 3), is a single passmembrane protein belonging to the armadillo repeat family of proteins.ARMCX3 contains three ARM repeats and shares 60% sequence similaritywith the related proteins, ARMCX1 and ARMCX2. ARMCX3 is believed toplay a role in embryonic development and tissue maintenance and may alsofunction as a tumor suppressor.

NCBI and Uniprot Product Information

• NCBI GI #: 7705274
• NCBI GeneID: 51566
• NCBI Accession #: NP_057691.1
• NCBI GenBank Nucleotide #: NM_016607.3
• UniProt Accession #: Q9UH62; Q53HC6; Q7LCF5; Q9NPE4
• Molecular Weight: 42,501 Da
• NCBI Official Full Name: armadillo repeat-containing X-linked protein 3
• NCBI Official Synonym Full Names: armadillo repeat containing, X-linked 3
• NCBI Official Symbol: ARMCX3
• NCBI Official Synonym Symbols: ALEX3; dJ545K15.2
• NCBI Protein Information: armadillo repeat-containing X-linked protein 3; 1200004E24Rik; arm protein lost in epithelial cancers, X chromosome, 3; ARM protein lost in epithelial cancers on chromosome X 3
• UniProt Protein Name: Armadillo repeat-containing X-linked protein 3
• Protein Family: Armadillo repeat-containing X-linked protein
• UniProt Gene Name: ARMCX3
• UniProt Synonym Gene Names: ALEX3; Protein ALEX3
• UniProt Entry Name: ARMX3_HUMAN

NCBI Description

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ARMCX3: an armadillo-repeat protein. Armadillo proteins function in multiple processes including intracellular signalling, cytoskeletal regulation, and transcriptional regulation. Armadillo proteins include beta-catenin, the junctional plaque protein plakoglobin, the adenomatous polyposis coli (APC) tumour suppressor protein, and the nuclear transport factor importin-alpha.

Protein type: Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: integral to mitochondrial outer membrane

Biological Process: positive regulation of transcription from RNA polymerase II promoter