Goat Arl6/BBS3 Polyclonal Antibody | anti-Arl6 antibody
Goat anti-Arl6/BBS3 (mouse) Antibody
Western Blot: Preliminary experiments gave an approx 33kDa band in Mouse Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 21. 0kDa according to NP_062639.3. The 33kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
Uniprot Description
ARL6: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. Defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55). RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF
Cellular Component: cell projection; cilium; cytoplasm; cytoskeleton; cytosol; intracellular; membrane; plasma membrane
Molecular Function: GTP binding; metal ion binding; nucleotide binding; protein binding
Biological Process: brain development; cell projection organization and biogenesis; cilium biogenesis; intermembrane transport; protein amino acid ADP-ribosylation; protein transport; Ras protein signal transduction; regulation of smoothened signaling pathway; small GTPase mediated signal transduction; transport; Wnt receptor signaling pathway
Disease: Bardet-biedl Syndrome 1
Research Articles on Arl6
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Product Notes
The Arl6 arl6 (Catalog #AAA422754) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Arl6/BBS3 (mouse) Antibody reacts with Expected from sequence similarity: Mouse, Rat, Cow, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's Arl6/BBS3 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments gave an approx 33kDa band in Mouse Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 21. 0kDa according to NP_062639.3. The 33kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the Arl6 arl6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: KPSNAQSQDI VPT. It is sometimes possible for the material contained within the vial of "Arl6/BBS3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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