Western Blot (WB)
(AQP3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).)
Rabbit AQP3 Polyclonal Antibody | anti-AQP3 antibody
AQP3 Antibody (Center)
Western Blot (WB)
(AQP3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).)
Western Blot (WB)
(AQP3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).)
Western Blot (WB)
(AQP3 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).)
Western Blot (WB)
(AQP3 Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).)
family of small integral membrane proteins related to the major
intrinsic protein (MIP or AQP0). Aquaporin 3 is localized at the
basal lateral membranes of collecting duct cells in the kidney. In
addition to its water channel function, aquaporin 3 has been found
to facilitate the transport of nonionic small solutes such as urea
and glycerol, but to a smaller degree. It has been suggested that
water channels can be functionally heterogeneous and possess water
and solute permeation mechanisms.
Kim, N.H., et al. J. Invest. Dermatol. 130(9):2231-2239(2010)
Ji, C., et al. Int. J. Mol. Med. 26(2):257-263(2010)
Melis, M., et al. Dis. Colon Rectum 53(6):936-943(2010)
Shen, L., et al. Biomed. Pharmacother. 64(5):313-318(2010)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]
Uniprot Description
AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, multi-pass; Channel, misc.; Transporter, aquaporin family; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: basolateral plasma membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; intercellular junction
Molecular Function: transporter activity; urea transmembrane transporter activity; water channel activity; glycerol channel activity
Biological Process: positive regulation of immune system process; glycerol transport; cellular water homeostasis; response to retinoic acid; water transport; excretion; odontogenesis; response to vitamin D; transport; renal water homeostasis; response to calcium ion; transmembrane transport; regulation of keratinocyte differentiation
Disease: Gil Blood Group
Research Articles on AQP3
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Product Notes
The AQP3 aqp3 (Catalog #AAA9203508) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 163-191. The AQP3 Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Bovine, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's AQP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the AQP3 aqp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AQP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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