Immunohistochemistry (IHC)
(Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE))
Rabbit anti-Human APRT Polyclonal Antibody | anti-APRT antibody
Anti-APRT Antibody (aa149-179) IHC-plus
WB (1:1000)
For long term storage store at -20 degree C.
Immunohistochemistry (IHC)
(Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human, Prostate: Formalin-Fixed Paraffin-Embedded (FFPE))
Western Blot (WB)
(APRT Antibody western blot of MCF-7 cell line and rat kidney tissue lysates (35 ug/lane). The APRT antibody detected the APRT protein (arrow).)
Western Blot (WB)
(APRT Antibody western blot of MCF-7 cell line and rat kidney tissue lysates (35 ug/lane). The APRT antibody detected the APRT protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
APRT: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Defects in APRT are the cause of adenine phosphoribosyltransferase deficiency (APRTD); also known as 2,8-dihydroxyadenine urolithiasis. An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones. Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein type: EC 2.4.2.7; Transferase; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: adenine binding; adenine phosphoribosyltransferase activity; AMP binding
Biological Process: adenine salvage; cellular response to insulin stimulus; grooming behavior; lactation; nucleobase, nucleoside and nucleotide metabolic process; purine base metabolic process; purine salvage
Disease: Adenine Phosphoribosyltransferase Deficiency
Research Articles on APRT
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Product Notes
The APRT aprt (Catalog #AAA249563) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-APRT Antibody (aa149-179) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's APRT can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P (5 ug/ml) WB (1:1000). Researchers should empirically determine the suitability of the APRT aprt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APRT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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