Rabbit anti-Human Apolipoprotein C-I Polyclonal Antibody | anti-APOC-1 antibody

Apolipoprotein C-I, CT (Apolipoprotein CI, Apo C-I, Apo CI, ApoC-I, APO C1, APOC1, APO-C1, APOC-1) (AP)

Cat. Num. AAA6463697

• Gene Names: APOC1; Apo-CI; ApoC-I; apo-CIB; apoC-IB
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: Apolipoprotein C-I; Polyclonal Antibody; CT (Apolipoprotein CI; Apo C-I; Apo CI; ApoC-I; APO C1; APOC1; APO-C1; APOC-1) (AP); anti-APOC-1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human APOC1.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.

• Applicable Applications for anti-APOC-1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:10-1:50; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human APOC1 (KLH).
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-APOC-1 antibody

Antibodies; Lipoproteins

References

1. Bahri, R., Lipids Health Dis 7(1), 46 (2008). 2. Meunier, J.C., J. Virol. 82(19), 9647-9656 (2008). 3. Nagelkerken, L., J. Invest. Dermatol. 128(5), 1165-1172 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 4502157
• NCBI GeneID: 341
• NCBI Accession #: NP_001636
• NCBI GenBank Nucleotide #: NM_001645.4
• UniProt Accession #: P02654; Q6IB97; B2R526
• Molecular Weight: 9 kDa (80aa) confirmed by MALDI-TOF
• NCBI Official Full Name: apolipoprotein C-I
• NCBI Official Synonym Full Names: apolipoprotein C1
• NCBI Official Symbol: APOC1
• NCBI Official Synonym Symbols: Apo-CI; ApoC-I; apo-CIB; apoC-IB
• NCBI Protein Information: apolipoprotein C-I
• UniProt Protein Name: Apolipoprotein C-I
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOC1
• UniProt Synonym Gene Names: APOC1B; Apo-CIB; ApoC-IB; Apo-CIB'; ApoC-IB'
• UniProt Entry Name: APOC1_HUMAN

NCBI Description

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Uniprot Description

APOC1: Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Belongs to the apolipoprotein C1 family.

Protein type: Lipid-binding; Inhibitor; Secreted, signal peptide; Secreted; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: chylomicron; endoplasmic reticulum

Molecular Function: phospholipase inhibitor activity; lipase inhibitor activity; phosphatidylcholine binding; fatty acid binding

Biological Process: positive regulation of catalytic activity; cholesterol metabolic process; negative regulation of cholesterol transport; cholesterol efflux; lipoprotein metabolic process; triacylglycerol metabolic process; phospholipid efflux; negative regulation of lipid catabolic process; negative regulation of receptor-mediated endocytosis; negative regulation of lipoprotein lipase activity; lipid metabolic process; regulation of cholesterol transport; negative regulation of lipid metabolic process; negative regulation of fatty acid biosynthetic process