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Immunohistochemistry (IHC)-Paraffin (The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7124755(APOBEC3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200))

Rabbit anti-Human APOBEC3G Polyclonal Antibody | anti-APOBEC3G antibody

APOBEC3G Antibody

Gene Names
APOBEC3G; A3G; ARCD; ARP9; ARP-9; CEM15; CEM-15; MDS019; bK150C2.7; dJ494G10.1
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
APOBEC3G; Polyclonal Antibody; APOBEC3G Antibody; apolipoprotein B mRNA editing enzyme; catalytic polypeptide-like 3G; anti-APOBEC3G antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Form/Format
Liquid; In Phosphate Buffered Saline, pH 7.4, 0.05% NaN3, and 40% Glycerol
Applicable Applications for anti-APOBEC3G antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
ELISA: 1:1000-1:2000
WB: 1:200-1:1000
IHC: 1:25-1:100
Immunogen
Fusion protein of human APOBEC3G
Immunogen Species
Human
Conjugate
Non-conjugated
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)-Paraffin

(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7124755(APOBEC3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200))

Immunohistochemistry (IHC)-Paraffin (The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7124755(APOBEC3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200))

Immunohistochemistry (IHC)-Paraffin

(The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using MBS7124755(APOBEC3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200))

Immunohistochemistry (IHC)-Paraffin (The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using MBS7124755(APOBEC3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200))

SDS-Page

(Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane 1-3: PC3 cells, Jurkat cells, Raji cells, Primary antibody: MBS7124755(APOBEC3G Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)

SDS-Page (Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane 1-3: PC3 cells, Jurkat cells, Raji cells, Primary antibody: MBS7124755(APOBEC3G Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)
Product Categories/Family for anti-APOBEC3G antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
384
NCBI Official Full Name
DNA dC->
NCBI Official Synonym Full Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
NCBI Official Symbol
APOBEC3G
NCBI Official Synonym Symbols
A3G; ARCD; ARP9; ARP-9; CEM15; CEM-15; MDS019; bK150C2.7; dJ494G10.1
NCBI Protein Information
DNA dC->dU-editing enzyme APOBEC-3G; deoxycytidine deaminase; APOBEC-related protein 9; DNA dC->dU editing enzyme; phorbolin-like protein MDS019; APOBEC-related cytidine deaminase; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprot
UniProt Protein Name
DNA dC->dU-editing enzyme APOBEC-3G
Protein Family
UniProt Gene Name
APOBEC3G
UniProt Synonym Gene Names
APOBEC-related protein; ARCD; ARP-9; CEM15; A3G
UniProt Entry Name
ABC3G_HUMAN

NCBI Description

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]

Uniprot Description

APOBEC3G: DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing. Belongs to the cytidine and deoxycytidylate deaminase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; EC 3.5.4.-; Hydrolase; RNA processing

Chromosomal Location of Human Ortholog: 22q13.1-q13.2

Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; cytosol; ribonucleoprotein complex

Molecular Function: protein binding; protein homodimerization activity; deoxycytidine deaminase activity; zinc ion binding; RNA binding; cytidine deaminase activity

Biological Process: negative regulation of retroviral genome replication; base conversion or substitution editing; viral reproduction; negative regulation of viral genome replication; innate immune response; cytidine deamination; positive regulation of defense response to virus by host; negative regulation of viral reproduction; defense response to virus

Research Articles on APOBEC3G

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Product Notes

The APOBEC3G apobec3g (Catalog #AAA7124755) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APOBEC3G Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's APOBEC3G can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:1000-1:2000 WB: 1:200-1:1000 IHC: 1:25-1:100. Researchers should empirically determine the suitability of the APOBEC3G apobec3g for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APOBEC3G, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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