Goat anti-Human APOB/Apolipoprotein B Polyclonal Antibody | anti-APOB antibody

Anti-APOB/Apolipoprotein B Antibody

Cat. Num. AAA2401626

• Gene Names: APOB; FLDB; LDLCQ4; apoB-48; apoB-100
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Functional Assay, Immunodiffusion, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: APOB/Apolipoprotein B; Polyclonal Antibody; Anti-APOB/Apolipoprotein B Antibody; Goat Polyclonal (IgG) to Human APOB/Apolipoprotein B; APOB; ApoB-100; Apolipoprotein B-48; ApoB-48; Apolipoprotein B; FLDB; LDLCQ4; Mutant Apo B 100; Apo B-100; Apolipoprotein B-100; Apolipoprotein B48; anti-APOB antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human Apolipoprotein B.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 10 mM sodium phosphate, 0.15 M sodium chloride, pH 7.2, 0.05% sodium azide.
• Sequence Length: 4563

• Applicable Applications for anti-APOB antibody: ELISA (EIA), Flow Cytometry (FC/FACS), Immunodiffusion (ID), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: IHC-P: 5 ug/ml
• Immunogen: Human Apolipoprotein B.
• Conjugation: Unconjugated
• Preparation and Storage: Store at 2 degree C to 8 degree C.

Immunohistochemistry (IHC)

(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-APOB antibody

(ApoB) is the main apolipoprotein of chylomicrons and low densitylipoproteins (LDL). The protein occurs in the plasma in 2 main isoforms, apoB-48 and apoB-100. The first is synthesized exclusively by the gut, the second by the liver. The intestinal (B-48) and hepatic (B-100) formsof apoB are coded by a single gene and by a single mRNA transcriptlarger than 16 kb. The 2 proteins share a common amino terminalsequence.

NCBI and Uniprot Product Information

• NCBI GI #: 105990532
• NCBI GeneID: 338
• NCBI Accession #: NP_000375.2
• NCBI GenBank Nucleotide #: NM_000384.2
• UniProt Accession #: P04114; O00502; P78479; P78480; P78481; Q13779; Q13785; Q13786; Q13787; Q13788; Q4ZG63; Q53QC8
• Molecular Weight: 515,605 Da
• NCBI Official Full Name: apolipoprotein B-100
• NCBI Official Synonym Full Names: apolipoprotein B
• NCBI Official Symbol: APOB
• NCBI Official Synonym Symbols: FLDB; LDLCQ4; apoB-48; apoB-100
• NCBI Protein Information: apolipoprotein B-100
• UniProt Protein Name: Apolipoprotein B-100
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOB
• UniProt Synonym Gene Names: Apo B-100; Apo B-48

NCBI Description

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]

Uniprot Description

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.