Western Blot (WB)
(Western Blot analysis of 3T3 cells using APLP-2 Polyclonal Antibody)
Rabbit APLP-2 Polyclonal Antibody | anti-APLP-2 antibody
APLP-2 Polyclonal Antibody
Immunohistochemistry: 1:100 - 1:300
ELISA: 1:40000
Not yet tested in other applications.
Western Blot (WB)
(Western Blot analysis of 3T3 cells using APLP-2 Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 3T3 cells using APLP-2 Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 293 NIH-3T3 cells using APLP-2 Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 293 NIH-3T3 cells using APLP-2 Polyclonal Antibody)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Uniprot Description
APLP2: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. Belongs to the APP family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Receptor, misc.; Membrane protein, integral; DNA-binding
Chromosomal Location of Human Ortholog: 11q24
Cellular Component: membrane; plasma membrane; integral to membrane; nucleus
Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; DNA binding; transition metal ion binding
Biological Process: cholesterol metabolic process; G-protein coupled receptor protein signaling pathway; extracellular matrix organization and biogenesis; cellular copper ion homeostasis; suckling behavior; regulation of protein binding; regulation of epidermal growth factor receptor activity; midbrain development; forebrain development; mating behavior; locomotory behavior; neuromuscular process controlling balance
Research Articles on APLP-2
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Product Notes
The APLP-2 aplp2 (Catalog #AAA9404280) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APLP-2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's APLP-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). Western Blot: 1:500 - 1:2000 Immunohistochemistry: 1:100 - 1:300 ELISA: 1:40000 Not yet tested in other applications. Researchers should empirically determine the suitability of the APLP-2 aplp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APLP-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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