Rabbit anti-Human APLNR Polyclonal Antibody | anti-APLNR antibody

APLNR, ID (APLNR, AGTRL1, APJ, Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11) (PE)

Cat. Num. AAA6274367

• Gene Names: APLNR; APJ; APJR; HG11; AGTRL1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: APLNR; Polyclonal Antibody; ID (APLNR; AGTRL1; APJ; Apelin receptor; Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11) (PE); G-protein coupled receptor HG11; anti-APLNR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-APLNR antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: APLNR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-244 amino acids from the Central region of human APLNR.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(APLNR Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the APLNR antibody detected the APLNR protein (arrow).)

Related Product Information for anti-APLNR antibody

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.

Product Categories/Family for anti-APLNR antibody

Antibodies; Angiotensin(ogen)

References

Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4237-4242(2010). Zhao, Q., et al. Am. J. Hypertens. 23(6):606-613(2010). Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010). Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14(3):231-241(2010). Peltonen, T., et al. J. Heart Valve Dis. 18(6):644-652(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4885057
• NCBI GeneID: 187
• NCBI Accession #: NP_005152.1
• NCBI GenBank Nucleotide #: NM_005161.4
• UniProt Accession #: P35414
• Molecular Weight: 42,660 Da
• NCBI Official Full Name: apelin receptor
• NCBI Official Synonym Full Names: apelin receptor
• NCBI Official Symbol: APLNR
• NCBI Official Synonym Symbols: APJ; APJR; HG11; AGTRL1
• NCBI Protein Information: apelin receptor; APJ receptor; HG11 orphan receptor; APJ (apelin) receptor; angiotensin receptor-like 1; G protein-coupled receptor APJ; G-protein coupled receptor APJ; angiotensin II receptor-like 1; G-protein coupled receptor HG11
• UniProt Protein Name: Apelin receptor
• Protein Family: Apelin receptor
• UniProt Gene Name: APLNR
• UniProt Synonym Gene Names: AGTRL1; APJ
• UniProt Entry Name: APJ_HUMAN

NCBI Description

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]

Uniprot Description

AGTRL1: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of body fluid levels; heart development; gastrulation