Rabbit Apelin Polyclonal Antibody | anti-APLN antibody

Apelin Rabbit pAb

Cat. Num. AAA4755068

• Gene Names: APLN; APEL; XNPEP2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: Apelin; Polyclonal Antibody; Apelin Rabbit pAb; APLN; APEL; APJ endogenous ligand; anti-APLN antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Apelin Polyclonal Antibody detects endogenous levels of Apelin protein.
• Purity/Purification: Affinity purified
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-APLN antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:100-300; ELISA: 1:20,000
• Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human APLN. AA range:28-77
• Conjugation: Unconjugated
• Nucleotide Accession: 8862
• Modification: Unmodified
• Cell Position: Secreted
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100)

Product Categories/Family for anti-APLN antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 45120090
• NCBI GeneID: 8862
• NCBI Accession #: NP_059109.3
• NCBI GenBank Nucleotide #: NM_017413.4
• UniProt Accession #: Q9ULZ1; Q4VY08; Q8WU89
• Molecular Weight: 8,569 Da
• NCBI Official Full Name: apelin preproprotein
• NCBI Official Synonym Full Names: apelin
• NCBI Official Symbol: APLN
• NCBI Official Synonym Symbols: APEL; XNPEP2
• NCBI Protein Information: apelin; AGTRL1 ligand; APJ endogenous ligand
• UniProt Protein Name: Apelin
• Protein Family: Apelin
• UniProt Gene Name: APLN
• UniProt Synonym Gene Names: APEL
• UniProt Entry Name: APEL_HUMAN

NCBI Description

This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]

Uniprot Description

apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: extracellular space; extracellular region

Molecular Function: G-protein-coupled receptor binding; hormone activity; apelin receptor binding; receptor binding

Biological Process: lactation; immune response; signal transduction