Western Blot (WB)
(APC Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the APC antibody detected the APC protein (arrow).)
Rabbit anti-Mouse APC Polyclonal Antibody | anti-APC antibody
APC Antibody (Center)
Western Blot (WB)
(APC Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the APC antibody detected the APC protein (arrow).)
Western Blot (WB)
(APC Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the APC antibody detected the APC protein (arrow).)
an antagonist of the Wnt signaling pathway. It is also involved in
other processes including cell migration and adhesion,
transcriptional activation, and apoptosis. Defects in this gene
cause familial adenomatous polyposis (FAP), an autosomal dominant
pre-malignant disease that usually progresses to malignancy.
Disease-associated mutations tend to be clustered in a small region
designated the mutation cluster region (MCR) and result in a
truncated protein product.
Rai, K., et al. Cell 142(6):930-942(2010)
Poulogiannis, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15145-15150(2010)
Jaulin, F., et al. J. Cell Biol. 190(3):443-460(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
Uniprot Description
APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 5q21-q22
Cellular Component: centrosome; tight junction; beta-catenin destruction complex; cytosol; kinetochore; nucleoplasm; cell-cell adherens junction; lamellipodium; cytoplasmic microtubule; cytoplasm; plasma membrane; nucleus; lateral plasma membrane
Molecular Function: microtubule plus-end binding; protein binding; cadherin binding; gamma-catenin binding; microtubule binding; beta-catenin binding; protein kinase regulator activity; protein kinase binding
Biological Process: positive regulation of cell adhesion; somatic stem cell maintenance; apoptosis; positive regulation of apoptosis; positive regulation of microtubule polymerization; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; cytoplasmic microtubule organization and biogenesis; anterior/posterior pattern formation; muscle maintenance; negative regulation of cell proliferation; regulation of osteoclast differentiation; cytokinesis after mitosis; hair follicle development; mitotic cell cycle spindle assembly checkpoint; positive regulation of epithelial cell differentiation; protein complex assembly; kidney development; cell cycle arrest; cell adhesion; proximal/distal pattern formation; cell structure disassembly during apoptosis; regulation of microtubule-based process; negative regulation of odontogenesis; cell migration; regulation of attachment of spindle microtubules to kinetochore; thymus development; regulation of osteoblast differentiation; negative regulation of microtubule depolymerization; negative regulation of MAPKKK cascade; axis specification; negative regulation of cyclin-dependent protein kinase activity; positive regulation of pseudopodium formation; dorsal/ventral pattern formation; axonogenesis; retina development in camera-type eye; positive regulation of cell division; positive regulation of protein catabolic process; regulation of nitrogen compound metabolic process; response to DNA damage stimulus; mitotic metaphase/anaphase transition; positive regulation of cell migration
Disease: Familial Adenomatous Polyposis 1; Gastric Cancer; Desmoid Disease, Hereditary; Colorectal Cancer; Hepatocellular Carcinoma
Research Articles on APC
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Product Notes
The APC apc (Catalog #AAA9209094) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1148-1176. The APC Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's APC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the APC apc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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