Rabbit anti-Human APBA3 Polyclonal Antibody | anti-APBA3 antibody

APBA3, ID (APBA3, MINT3, X11L2, Amyloid beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3) (FITC)

Cat. Num. AAA6274173

• Gene Names: APBA3; X11L2; mint3; MGC:15815
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: APBA3; Polyclonal Antibody; ID (APBA3; MINT3; X11L2; Amyloid beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3) (FITC); Neuronal Munc18-1-interacting protein 3; anti-APBA3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-APBA3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: APBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the Central region of human APBA3.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(APBA3 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the APBA3 antibody detected the APBA3 protein (arrow).)

Related Product Information for anti-APBA3 antibody

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.

Product Categories/Family for anti-APBA3 antibody

Antibodies; Amyloid

References

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009). Sakamoto, T., et al. J. Biol. Chem. 284(44):30350-30359(2009). Han, J., et al. J. Cell. Sci. 121 (PT 13), 2217-2223 (2008): Shrivastava-Ranjan, P., et al. Mol. Biol. Cell 19(1):51-64(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 11342678
• NCBI GeneID: 9546
• NCBI Accession #: NP_004877.1
• NCBI GenBank Nucleotide #: NM_004886.3
• UniProt Accession #: O96018; O60483; Q9UPZ2
• Molecular Weight: 61,454 Da
• NCBI Official Full Name: amyloid beta A4 protein-binding family A member 3
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family A, member 3
• NCBI Official Symbol: APBA3
• NCBI Official Synonym Symbols: X11L2; mint3; MGC:15815
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family A member 3; mint-3; X11-like 2 protein; adapter protein X11gamma; neuron-specific X11L2 protein; neuronal munc18-1-interacting protein 3; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; a
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family A member 3
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: APBA3
• UniProt Synonym Gene Names: MINT3; X11L2; Mint-3
• UniProt Entry Name: APBA3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [provided by RefSeq, Jul 2008]

Uniprot Description

APBA3: May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: perinuclear region of cytoplasm

Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding; beta-amyloid binding

Biological Process: synaptic transmission; protein transport; regulation of gene expression; in utero embryonic development; negative regulation of catalytic activity