Rabbit anti-Human, Mouse APBA1 Polyclonal Antibody | anti-APBA1 antibody

APBA1 Rabbit pAb

Cat. Num. AAA4754759

• Gene Names: APBA1; X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: APBA1; Polyclonal Antibody; APBA1 Rabbit pAb; X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA; anti-APBA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-APBA1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Synthetic peptide of human APBA1
• Conjugation: Unconjugated
• Molecular Function: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
• Modification: Unmodified
• Cell Position: Cytoplasm, Golgi apparatus, Nucleus
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 8%SDS-PAGE, Lysate: 50 ug, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: 161288(APBA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds)

Product Categories/Family for anti-APBA1 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 22035548
• NCBI GeneID: 320
• NCBI Accession #: NP_001154
• NCBI GenBank Nucleotide #: NM_001163.3
• UniProt Accession #: Q02410; O14914; O60570; Q5VYR8
• Molecular Weight: 92 kDa
• NCBI Official Full Name: amyloid beta A4 protein-binding family A member 1
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family A, member 1
• NCBI Official Symbol: APBA1
• NCBI Official Synonym Symbols: X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family A member 1; mint-1; adapter protein X11alpha; adaptor protein X11alpha; neuron-specific X11 protein; neuronal munc18-1-interacting protein 1; phosphotyrosine-binding/-interacting domain (PTB)-bearing protei
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family A member 1
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: APBA1
• UniProt Synonym Gene Names: MINT1; X11; Mint-1
• UniProt Entry Name: APBA1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2008]

Uniprot Description

APBA1: Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q21.12

Cellular Component: Golgi apparatus; synaptic vesicle; protein complex; perinuclear region of cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-amyloid binding; protein complex binding; PDZ domain binding

Biological Process: intracellular protein transport; synaptic transmission; nervous system development; glutamate secretion; regulation of gene expression; in utero embryonic development; multicellular organism growth; gamma-aminobutyric acid secretion; axon cargo transport; locomotory behavior; protein complex assembly; cell adhesion