Rabbit AP3M1 Polyclonal Antibody | anti-AP3M1 antibody

Rabbit Polyclonal to Human AP3M1

Cat. Num. AAA243438

• Reactivity: Bovine, Chicken, Dog, Hamster, Horse, Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Protein A Purified
• Synonyms: AP3M1; Polyclonal Antibody; Rabbit Polyclonal to Human AP3M1; Anti-AP3M1 Antibody (aa140-190) IHC-plus; AP-3 complex subunit mu-1; Mu3A-adaptin; Mu-adaptin 3A; Human AP3M1; anti-AP3M1 antibody

• Host: Rabbit
• Reactivity: Bovine, Chicken, Dog, Hamster, Horse, Human
• Clonality: Polyclonal
• Specificity: Human AP3M1
• Purity/Purification: Protein A Purified
• Form/Format: PBS, 0.05% BSA, 0.05% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 418

• Applicable Applications for anti-AP3M1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB (3 - 5 ug/ml)
• Target Species: Human
• Immunogen Description: Amino acids 140-190 of human AP3 subunit M1.
• Immunogen Type: Synthetic peptide
• Immunogen: AP3M1 antibody was raised against amino acids 140-190 of human AP3 subunit M1.
• Antigen Modification: aa140-190
• Preparation and Storage: Store at 4 degree C, stable for 6 months. For long term storage, aliquot and store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-AP3M1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 6912240
• NCBI GeneID: 26985
• NCBI Accession #: NP_036227.1
• NCBI GenBank Nucleotide #: NM_012095.4
• UniProt Accession #: Q9Y2T2; Q5JQ12; Q9H5L2
• Molecular Weight: 46,939 Da
• NCBI Official Full Name: AP-3 complex subunit mu-1
• NCBI Official Synonym Full Names: adaptor-related protein complex 3, mu 1 subunit
• NCBI Official Symbol: AP3M1
• NCBI Protein Information: AP-3 complex subunit mu-1; mu3A-adaptin; mu-adaptin 3A; AP-3 adapter complex mu3A subunit; AP-3 adaptor complex mu3A subunit; clathrin adaptor complex AP3, mu-3A subunit; adapter-related protein complex 3 mu-1 subunit; adapter-related protein complex 3 subunit mu-1; adaptor-related protein complex 3 subunit mu-1
• UniProt Protein Name: AP-3 complex subunit mu-1
• Protein Family: AP-3 complex
• UniProt Gene Name: AP3M1
• UniProt Entry Name: AP3M1_HUMAN

NCBI Description

The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

AP3M1: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes medium subunit family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: Golgi apparatus; clathrin adaptor complex; cytoplasmic vesicle membrane; lysosome; lysosomal membrane

Molecular Function: protein binding; Rab GTPase binding

Biological Process: protein targeting to lysosome; anterograde synaptic vesicle transport; anterograde axon cargo transport