Rabbit anti-Human ANXA13 Polyclonal Antibody | anti-ANXA13 antibody

ANXA13, NT (ANXA13, ANX13, Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin) (FITC)

Cat. Num. AAA6273931

• Gene Names: ANXA13; ISA; ANX13
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ANXA13; Polyclonal Antibody; NT (ANXA13; ANX13; Annexin A13; Annexin XIII; Annexin-13; Intestine-specific annexin) (FITC); Intestine-specific annexin; anti-ANXA13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 316

• Applicable Applications for anti-ANXA13 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ANXA13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ANXA13.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ANXA13 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the ANXA13 antibody detected the ANXA13 protein (arrow).)

Related Product Information for anti-ANXA13 antibody

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified.

Product Categories/Family for anti-ANXA13 antibody

Antibodies; Annexin

References

Reiske, H., et al. Anal. Quant. Cytol. Histol. 32(2):61-69(2010). Anderson, N.L., et al. Mol. Cell Proteomics 3(4):311-326(2004). Iglesias, J.M., et al. Mol. Biol. Evol. 19(5):608-618(2002). Noda, Y., et al. J. Cell Biol. 155(1):77-88(2001). Plant, P.J., et al. J. Cell Biol. 149(7):1473-1484(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 51895795
• NCBI GeneID: 312
• NCBI Accession #: NP_004297.2
• NCBI GenBank Nucleotide #: NP_004297.2
• UniProt Accession #: P27216
• NCBI Official Full Name: annexin A13 isoform a
• NCBI Official Synonym Full Names: annexin A13
• NCBI Official Symbol: ANXA13
• NCBI Official Synonym Symbols: ISA; ANX13
• NCBI Protein Information: annexin A13
• UniProt Protein Name: Annexin A13
• Protein Family: Annexin
• UniProt Gene Name: ANXA13
• UniProt Synonym Gene Names: ANX13; ISA
• UniProt Entry Name: ANX13_HUMAN

NCBI Description

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

ANXA13: a calcium/phospholipid-binding protein associated with the cell membrane. ANXA13 is the probable common ancestor of the annexin family of proteins. Annexins all bind to phospholipids in a calcium-dependent manner. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Lipid-binding; Calcium-binding

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: nucleoplasm; extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft

Molecular Function: calcium-dependent phospholipid binding; phosphatidylserine binding; calcium ion binding; phosphatidylcholine binding

Biological Process: negative regulation of Golgi to plasma membrane protein transport; positive regulation of Golgi to plasma membrane protein transport; cell differentiation