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Rabbit anti-Human, Mouse ANXA13 Polyclonal Antibody | anti-ANXA13 antibody

ANXA13 Antibody

Gene Names
ANXA13; ISA; ANX13
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
ANXA13; Polyclonal Antibody; ANXA13 Antibody; Annexin A13; Annexin XIII; Annexin; intestine-specific; Annexin-13; ANX 13; ANX A13; ANX13; ANX13_HUMAN; Intestine Specific Annexin; Intestine-specific annexin; ISA; MGC150460; anti-ANXA13 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
ANXA13 Antibody detects endogenous levels of ANXA13.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ANXA13 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human ANXA13.
Conjugation
Unconjugated
Similarity
A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family.
Subunit Structure
Monomer and homodimer.
Tissue Specificity
Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.
Function
Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup.Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.
Note
Myristoylation anchors the protein to the membrane, but the protein displays also calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-ANXA13 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
312
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39,744 Da
NCBI Official Full Name
annexin A13 isoform b
NCBI Official Synonym Full Names
annexin A13
NCBI Official Symbol
ANXA13
NCBI Official Synonym Symbols
ISA; ANX13
NCBI Protein Information
annexin A13; annexin XIII; annexin, intestine-specific; annexin-13; intestine-specific annexin
UniProt Protein Name
Annexin A13
Protein Family
UniProt Gene Name
ANXA13
UniProt Synonym Gene Names
ANX13; ISA
UniProt Entry Name
ANX13_HUMAN

NCBI Description

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

ANXA13: a calcium/phospholipid-binding protein associated with the cell membrane. ANXA13 is the probable common ancestor of the annexin family of proteins. Annexins all bind to phospholipids in a calcium-dependent manner. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Lipid-binding; Calcium-binding

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: nucleoplasm; extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft

Molecular Function: calcium-dependent phospholipid binding; phosphatidylserine binding; calcium ion binding; phosphatidylcholine binding

Biological Process: negative regulation of Golgi to plasma membrane protein transport; positive regulation of Golgi to plasma membrane protein transport; cell differentiation

Research Articles on ANXA13

Similar Products

Product Notes

The ANXA13 anxa13 (Catalog #AAA9630607) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ANXA13 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ANXA13 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the ANXA13 anxa13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ANXA13, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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