Rabbit anti-Bacteria Anthrax Edema Factor Polyclonal Antibody | anti-pxo1_122 antibody
Anthrax Edema Factor Antibody
Reactivity
Bacteria
Applications
ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
Anthrax Edema Factor; Polyclonal Antibody; Anthrax Edema Factor Antibody; Anthrax EF; anti-pxo1_122 antibody
Host
Rabbit
Reactivity
Bacteria
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
800
Applicable Applications for anti-pxo1_122 antibody
ELISA (EIA)
Immunogen Type
Peptide
Immunogen Description
Raised against a synthetic peptide corresponding to 16 amino acids near the carboxy terminus of the Anthrax edema factor protein.
Target Name
Anthrax Edema Factor
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Product Information for anti-pxo1_122 antibody
Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++-dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system.
Product Categories/Family for anti-pxo1_122 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
92,478 Da
NCBI Official Full Name
pXO1-122 (plasmid)
NCBI Official Symbol
pxo1_122
NCBI Protein Information
pXO1-122
UniProt Protein Name
Calmodulin-sensitive adenylate cyclase
UniProt Gene Name
cya
UniProt Synonym Gene Names
EF
UniProt Entry Name
CYAA_BACAN
Uniprot Description
One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. EF is a calmodulin-dependent adenylyl cyclase that, when associated with PA, causes edema. EF is not toxic by itself and it is required for the survival of germinated spores within macrophages at the early stages of infection. Provokes dramatic elevation of intracellular cAMP levels in the host.
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Product Notes
The pxo1_122 cya (Catalog #AAA9408175) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anthrax Edema Factor Antibody reacts with Bacteria and may cross-react with other species as described in the data sheet. AAA Biotech's Anthrax Edema Factor can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the pxo1_122 cya for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Anthrax Edema Factor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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