Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-1.JPGIHC(P): Human Intestinal Cancer Tissue )
Rabbit Annexin V Polyclonal Antibody | anti-ANXA5 antibody
Anti-Annexin V Antibody
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-1.JPGIHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-1.JPGIHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-2.JPGIHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-2.JPGIHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-3.JPGIHC(P): Mouse Kidney Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-3.JPGIHC(P): Mouse Kidney Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-4.JPGIHC(P): Rat Kidney Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin V Picoband antibody, MBS177096-4.JPGIHC(P): Rat Kidney Tissue )
Testing Data
(Anti-Annexin V Picoband antibody, MBS177096-5.jpgAll lanes: Anti-Annexin V(MBS177096) at 0.5ug/mlLane 1: Rat Lung Tissue Lysate at 40ugLane 2: Rat Brain Tissue Lysate at40ugLane 3: Rat Cardiac Muscle Tissue Lysate at 40ugLane 4: Rat Kidney Tissue Lysate at 40ugLane 5: HELA Whole Cell Lysate at 40ugLane 6: SMMC Whole Cell Lysate at 40ugLane 7: A549 Whole Cell Lysate at 40ugLane 8: SGC Whole Cell Lysate at 40ugPredicted bind size: 36KDObserved bind size: 36KD)
Testing Data
(Anti-Annexin V Picoband antibody, MBS177096-5.jpgAll lanes: Anti-Annexin V(MBS177096) at 0.5ug/mlLane 1: Rat Lung Tissue Lysate at 40ugLane 2: Rat Brain Tissue Lysate at40ugLane 3: Rat Cardiac Muscle Tissue Lysate at 40ugLane 4: Rat Kidney Tissue Lysate at 40ugLane 5: HELA Whole Cell Lysate at 40ugLane 6: SMMC Whole Cell Lysate at 40ugLane 7: A549 Whole Cell Lysate at 40ugLane 8: SGC Whole Cell Lysate at 40ugPredicted bind size: 36KDObserved bind size: 36KD)
Background: Annexin A5 (or annexin V) is a cellular protein in the annexin group. It is mapped to 4q27. Annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. This protein is an anticoagulant protein, it can form a shield around negatively-charged phospholipid molecules, the formation of an annexin A5 shield blocks the entry of phospholipids into coagulation (clotting) reactions. And Annexin A5 can also act as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
Uniprot Description
ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Apoptosis; Inhibitor; Lipid-binding; Calcium-binding
Chromosomal Location of Human Ortholog: 4q27
Cellular Component: focal adhesion; membrane; cytoplasm; intracellular; external side of plasma membrane
Molecular Function: phospholipase inhibitor activity; calcium-dependent phospholipid binding; phospholipid binding; calcium ion binding
Biological Process: response to organic substance; negative regulation of catalytic activity; negative regulation of coagulation; signal transduction; blood coagulation; negative regulation of apoptosis
Disease: Pregnancy Loss, Recurrent, Susceptibility To, 3
Research Articles on ANXA5
Similar Products
Product Notes
The ANXA5 anxa5 (Catalog #AAA177096) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Annexin V Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Annexin V can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the ANXA5 anxa5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Annexin V, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
