Rabbit ANGPTL4, coiled-coil domain Polyclonal Antibody | anti-ANGPTL3 antibody

ANGPTL4, coiled-coil domain (Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein)

Cat. Num. AAA6007738

• Gene Names: ANGPTL3; ANL3; ANG-5; FHBL2; ANGPT5
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ANGPTL4; coiled-coil domain; Polyclonal Antibody; coiled-coil domain (Angiopoietin-like Protein 4; FIAF; Fasting-induced Adipose Factor; HFARP; Hepatic Fibrinogen/Angiopoietin-related Protein); Anti -ANGPTL4; anti-ANGPTL3 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Recognizes the coiled-coil domain of human ANGPTL4. Detects a band of ~19kD by Western blot. Weakly cross-reacts with human ANGPTL2 (coiled-coil domain), ANGPTL3 and ANGPTL5 (coiled-coil domain).
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.

• Applicable Applications for anti-ANGPTL3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA, Western Blot
• Immunogen: Coiled-coil domain of recombinant human ANGPTL4.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis using anti-ANGPTL4 (CCD) (human), pAb at 1:2'000 dilution. 1: Human ANGPTL4 (CDD) (DYKDDDDK-tagged). 2: Human ANGPTL4 (DYKDDDDK-tagged). 3: Human ANGPTL3 (CCD) (DYKDDDDK-tagged). 4: Human ANGPTL3 (DYKDDDDK-tagged). 5: Human ANGPTL3 (FLD) (DYKDDDDK-tagged). 6: Human ANGPTL2 (CCD) (DYKDDDDK-tagged). 7: Human ANGPTL5 (CCD) (DYKDDDDK-tagged).)

Related Product Information for anti-ANGPTL3 antibody

ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.

Product Categories/Family for anti-ANGPTL3 antibody

Antibodies; Abs to Angiopoietin

NCBI and Uniprot Product Information

• NCBI GI #: 7656888
• NCBI GeneID: 27329
• NCBI Accession #: NP_055310.1
• NCBI GenBank Nucleotide #: NM_014495.3
• UniProt Accession #: Q9Y5C1
• Molecular Weight: 53,637 Da
• NCBI Official Full Name: angiopoietin-related protein 3 preproprotein
• NCBI Official Synonym Full Names: angiopoietin-like 3
• NCBI Official Symbol: ANGPTL3
• NCBI Official Synonym Symbols: ANL3; ANG-5; FHBL2; ANGPT5
• NCBI Protein Information: angiopoietin-related protein 3; angiopoietin 5
• UniProt Protein Name: Angiopoietin-related protein 3
• Protein Family: Angiopoietin-related protein
• UniProt Gene Name: ANGPTL3
• UniProt Synonym Gene Names: ANGPT5; ANG-5
• UniProt Entry Name: ANGL3_HUMAN

NCBI Description

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]

Uniprot Description

ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.

Protein type: Inhibitor; Cell adhesion; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: extracellular space; cell surface

Molecular Function: integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity

Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; glycerol metabolic process; phospholipid catabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; sequestering of lipid; cholesterol homeostasis; positive regulation of angiogenesis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; positive regulation of cell migration; phospholipid homeostasis

Disease: Hypobetalipoproteinemia, Familial, 2