Testing Data
(Anti-ACE Picoband antibody, MBS177457-1.jpgAll lanes: Anti ACE (MBS177457) at 0.5ug/mlWB: Recombinant Human ACE Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Rabbit Angiotensin-converting enzyme Polyclonal Antibody | anti-ACE antibody
Anti-ACE Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat
Immunohistochemistry (Frozen Section): Concentration: 0.5-1mug/ml; Tested Species: Mouse
Testing Data
(Anti-ACE Picoband antibody, MBS177457-1.jpgAll lanes: Anti ACE (MBS177457) at 0.5ug/mlWB: Recombinant Human ACE Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Testing Data
(Anti-ACE Picoband antibody, MBS177457-1.jpgAll lanes: Anti ACE (MBS177457) at 0.5ug/mlWB: Recombinant Human ACE Protein 0.5ngPredicted bind size: 47KDObserved bind size: 47KD )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-2.JPGIHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-2.JPGIHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-3.JPGIHC(P): Mouse Lung Tissue )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-3.JPGIHC(P): Mouse Lung Tissue )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-4.JPGIHC(P): Rat Lung Tissue )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-4.JPGIHC(P): Rat Lung Tissue )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-5.JPGIHC(P): Rat Lung Tissue )
Immunohistochemistry (IHC)
(Anti-ACE Picoband antibody, MBS177457-5.JPGIHC(P): Rat Lung Tissue )
Background: Angiotensin-converting enzyme (ACE), an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system(RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II. Using a DNA marker at the growth hormone gene locus, which they characterized as 'extremely polymorphic' and which showed no recombination with ACE, ACE was mapped to 17q22-q24, consistent with the in situ hybridization mapping to 17q23. ACE, or kininase II, is a dipeptidyl carboxypeptidase that plays an important role in blood pressure regulation and electrolyte balance by hydrolyzing angiotensin I into angiotensin II, a potent vasopressor, and aldosterone-stimulating peptide. The enzyme is also able to inactivate bradykinin, a potent vasodilator.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Uniprot Description
ACE: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. Genetic variations in ACE may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in ACE are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Genetic variations in ACE are associated with susceptibility to microvascular complications of diabetes type 3 (MVCD3). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in ACE are a cause of susceptibility to intracerebral hemorrhage (ICH). A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the peptidase M2 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Membrane protein, integral; EC 3.4.15.1
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: extracellular space; lysosome; plasma membrane; extracellular region; integral to membrane; endosome; external side of plasma membrane
Molecular Function: tripeptidyl-peptidase activity; peptidyl-dipeptidase activity; zinc ion binding; metallopeptidase activity; carboxypeptidase activity; mitogen-activated protein kinase kinase binding; drug binding; actin binding; protein binding; bradykinin receptor binding; endopeptidase activity; exopeptidase activity; mitogen-activated protein kinase binding; chloride ion binding
Biological Process: mononuclear cell proliferation; regulation of vasodilation; angiotensin mediated regulation of renal output; neutrophil mediated immunity; regulation of angiotensin metabolic process; proteolysis; angiotensin maturation; arachidonic acid secretion; regulation of systemic arterial blood pressure by renin-angiotensin; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; regulation of smooth muscle cell migration; heart contraction; regulation of vasoconstriction; peptide catabolic process; beta-amyloid metabolic process; regulation of blood pressure; angiotensin catabolic process in blood; spermatogenesis; hormone catabolic process; blood vessel remodeling; kidney development
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 3; Renal Tubular Dysgenesis; Alzheimer Disease; Hemorrhage, Intracerebral, Susceptibility To
Research Articles on ACE
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Product Notes
The ACE ace (Catalog #AAA177457) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ACE Antibody reacts with Human, Mouse, Rat. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Angiotensin-converting enzyme can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-F). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human, Mouse Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat Immunohistochemistry (Frozen Section): Concentration: 0.5-1mug/ml; Tested Species: Mouse. Researchers should empirically determine the suitability of the ACE ace for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Angiotensin-converting enzyme, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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