Immunohistochemistry (IHC)
(Anti-ANAPC10 / APC10 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit ANAPC10 / APC10 Polyclonal Antibody | anti-ANAPC10 antibody
Rabbit Polyclonal to Human ANAPC10 / APC10
Usage: APC10 antibody can be used for detection of APC10 by Western blot at 1-2 ug/ml.
Immunohistochemistry (IHC)
(Anti-ANAPC10 / APC10 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-ANAPC10 / APC10 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunofluorescence (IF)
(Immunofluorescence of APC10 in mouse heart tissue with APC10 antibody at 20 µg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of APC10 in mouse heart tissue with APC10 antibody at 20 µg/mL.)
Western Blot (WB)
(Western blot of APC10 in mouse heart tissue lysate with APC10 antibody at (A) 1 and (B) 2 ug/ml.)
Western Blot (WB)
(Western blot of APC10 in mouse heart tissue lysate with APC10 antibody at (A) 1 and (B) 2 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Uniprot Description
APC10: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC10 family.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4q31
Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
Research Articles on ANAPC10
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Product Notes
The ANAPC10 anapc10 (Catalog #AAA248192) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human ANAPC10 / APC10 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ANAPC10 / APC10 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). ELISA, IF (20 ug/ml), IHC-P (5 ug/ml), WB (1 - 2 ug/ml) Usage: APC10 antibody can be used for detection of APC10 by Western blot at 1-2 ug/ml. Researchers should empirically determine the suitability of the ANAPC10 anapc10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ANAPC10 / APC10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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