Rabbit anti-Human Amylin Peptide Polyclonal Antibody | anti-IAPP antibody

Rabbit anti Amylin Peptide Polyclonal Antibody

Cat. Num. AAA460173

• Gene Names: IAPP; DAP; IAP
• Reactivity: Human
• Applications: ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Purified by Epitope Affinity Purification
• Synonyms: Amylin Peptide; Polyclonal Antibody; Rabbit anti Amylin Peptide Polyclonal Antibody; Amylin peptide; anti-IAPP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This antibody recognizes ~10 kDa of human Amylin protein. The other species are not tested.
• Purity/Purification: Purified by Epitope Affinity Purification
• Form/Format: Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Sequence Length: 62

• Applicable Applications for anti-IAPP antibody: ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: ELISA: 0.01-0.1 ug/ml; Flow Cytometry: 5-10 ug/ml; Immunohistochemistry: 2-10 ug/ml; Immunoprecipitation: 2-5 ug/ml; Western Blot: 0.1-1 ug/ml
• Preparation: A synthetic peptide derived from N-term of human Amylin peptide.
• Preparation and Storage: The antibodies are stable for 12 months from date of receipt when stored at -20 degree C. The antibodies can be stored at 2 degree C - 8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Related Product Information for anti-IAPP antibody

Amylin is a 37 amino acid peptide co-secreted with insulin from pancreatic islet beta-cells. Amylin shares structural similarities with calcitonin gene-related peptide (CGRP) and calcitonin (CT), including an N-terminal ring structure linked by a disulfide bridge, and an amidated C-terminus. The function of Amylin is to maintain the gluocose homoeostasis, include lowered insulin secretion, raised hepatic glucose output, stimulation of glycogenolysis and inhibition of glycogen synthesis in liver cells and in skeletal muscle. Amylin peptide is predominantly found in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and nervous system. This antibody can be used for staining of amylin in normal and diabetic pancreas and pancreatic carcinoma

NCBI and Uniprot Product Information

• NCBI GI #: 457131
• NCBI GeneID: 3375
• Molecular Weight: 9,806 Da
• NCBI Official Full Name: amylin, partial
• NCBI Official Synonym Full Names: islet amyloid polypeptide
• NCBI Official Symbol: IAPP
• NCBI Official Synonym Symbols: DAP; IAP
• NCBI Protein Information: islet amyloid polypeptide
• UniProt Protein Name: Islet amyloid polypeptide
• Protein Family: Islet amyloid polypeptide
• UniProt Gene Name: IAPP
• UniProt Synonym Gene Names: DAP

NCBI Description

This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]

Uniprot Description

IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: extracellular region

Molecular Function: beta-amyloid binding; identical protein binding; receptor binding

Biological Process: apoptosis; cell-cell signaling; cellular protein metabolic process; negative regulation of protein homooligomerization; positive regulation of apoptosis; protein homooligomerization; signal transduction