Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: ACY1 knockout K562 cell lysate; Predicted MW: 46,42,38kd Observed MW: 44kd Primary Ab: 2ug/ml Rabbit Anti-Human ACY1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Aminoacylase 1 (ACY1) Polyclonal Antibody | anti-ACY1 antibody
APC-Linked Polyclonal Antibody to Aminoacylase 1 (ACY1)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: ACY1 knockout K562 cell lysate; Predicted MW: 46,42,38kd Observed MW: 44kd Primary Ab: 2ug/ml Rabbit Anti-Human ACY1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: ACY1 knockout K562 cell lysate; Predicted MW: 46,42,38kd Observed MW: 44kd Primary Ab: 2ug/ml Rabbit Anti-Human ACY1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
Uniprot Description
ACY1: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Belongs to the peptidase M20A family.
Protein type: Amino Acid Metabolism - arginine and proline; EC 3.5.1.14; Hydrolase
Chromosomal Location of Human Ortholog: 3p21.2
Cellular Component: cytosol
Molecular Function: aminoacylase activity; identical protein binding; protein binding; zinc ion binding
Biological Process: peptide catabolic process; xenobiotic metabolic process
Disease: Aminoacylase 1 Deficiency
Research Articles on ACY1
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Product Notes
The ACY1 acy1 (Catalog #AAA2064485) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APC-Linked Polyclonal Antibody to Aminoacylase 1 (ACY1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Aminoacylase 1 (ACY1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the ACY1 acy1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Aminoacylase 1 (ACY1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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