Immunohistochemistry (IHC)
(Immunochemical staining of human AMDHD2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human AMDHD2 Polyclonal Antibody | anti-AMDHD2 antibody
Anti-AMDHD2 Antibody, Rabbit Polyclonal
Gene Names
AMDHD2; CGI-14
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
AMDHD2; Polyclonal Antibody; Anti-AMDHD2 Antibody; Rabbit Polyclonal; AMDHD2 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-CGI-14 Antibody; anti-AMDHD2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human AMDHD2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-AMDHD2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:500-1:2000
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human AMDHD2
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human AMDHD2, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human AMDHD2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human AMDHD2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-AMDHD2 antibody
AMDHD2 (Amidohydrolase Domain Containing 2) is located on human chromosome 16p13.3. The AMDHD2 protein is ubiquitously expressed in spleen, kidney and other tissues. Structurally, the encoded protein is reported to be 43748 Da in mass. AMDHD2 is associated with some diseases, including Tick-Borne Relapsing Fever and Eumycotic Mycetoma. AMDHD2 is related to hydrolase activity and N-acetylglucosamine-6-phosphate deacetylase activity. An important paralog of this gene is ENSG00000259784. AMDHD2 hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
References
Bergfeld AK, et al. (2012) Metabolism of vertebrate amino sugars with n-glycolyl groups: Elucidating the intracellular fate of the non-human sialic acid n-glycolylneuraminic acid. J Biol Chem 287 (34): 28865-28881.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
63,595 Da
NCBI Official Full Name
N-acetylglucosamine-6-phosphate deacetylase isoform 2
NCBI Official Synonym Full Names
amidohydrolase domain containing 2
NCBI Official Symbol
AMDHD2
NCBI Official Synonym Symbols
CGI-14
NCBI Protein Information
N-acetylglucosamine-6-phosphate deacetylase
UniProt Protein Name
N-acetylglucosamine-6-phosphate deacetylase
UniProt Gene Name
AMDHD2
UniProt Synonym Gene Names
GlcNAc 6-P deacetylaseCurated
Uniprot Description
AMDHD2: Belongs to the NagA family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 3.5.1.25; Hydrolase
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytosol; nucleus
Molecular Function: metal ion binding; N-acetylglucosamine-6-phosphate deacetylase activity; protein binding
Biological Process: carbohydrate metabolic process; N-acetylglucosamine catabolic process; N-acetylneuraminate catabolic process; UDP-N-acetylglucosamine biosynthetic process
Similar Products
Product Notes
The AMDHD2 amdhd2 (Catalog #AAA8102086) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-AMDHD2 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AMDHD2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the AMDHD2 amdhd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AMDHD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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